The International Journal of Biological Markers, 1994 From a panel of 4 murine monoclonal antibodies directed against keratin 19 various antibody combinations were evaluated in solid-phase enzyme-linked sandwich immunoassays for detection of soluble keratin 19 fragments in patient sera.
H. Bodenmüller +5 more
doaj +1 more source
Journal of Translational Medicine, 2019 Background The use of one-step nucleic acid amplification (OSNA) allows for lymph node (LN) metastasis to be detected rapidly and accurately. We conducted a prospective single-centre clinical trial to evaluate OSNA assay in detecting LN metastasis of ...
María Escalante Pérez +6 more
doaj +1 more source
Cross-talk between microRNA-let7c and transforming growth factor-β2 during epithelial-to-mesenchymal transition of retinal pigment epithelial cells [PDF]
International Journal of Ophthalmology, 2020 AIM: To explore the roles of microRNA-let7c (miR-let7c) and transforming growth factor-β2 (TGF-β2) and cellular signaling during epithelial-to-mesenchymal transition (EMT) of retinal pigment epithelial cells. METHODS: Retinal pigment epithelial (ARPE-19)
Qu-Zhen Deji +5 more
doaj +1 more source
Keratin-Templated Synthesis of Metallic Oxide Nanoparticles as MRI Contrast Agents and Drug Carriers
, 2018 Keratin is a family of cysteine-rich structural fibrous proteins abundantly present in skin and skin appendages. Inspired by the template synthesis strategy, in this work, keratin was utilized for the first time as a platform template to synthesize ...
Chen Peng (429537) +4 more
core +1 more source
Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization
Advanced Materials, EarlyView.A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab +8 more
wiley +1 more source
Immune Cells Profiles in the Different Sites of COVID-19-Affected Lung Lobes in a Single Patient
Frontiers in Medicine, 2022 Whereas the COVID-19 disease pathophysiology is under investigation, it is important to identify the pathways of viral transmission and inflammation from the pre-illness to the disease-onset stages.
Sadahiro Iwabuchi +8 more
doaj +1 more source
A Ca2+-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics
, 2022 Keratins exert important structural but also cytoprotective functions. They have to be adaptable to support cellular homeostasis. Epiplakin (EPPK1) has been shown to decorate keratin filaments in epithelial cells and to play a protective role under ...
Rudolf E. Leube +9 more
core +1 more source
TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes
Advanced Science, EarlyView.In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang +11 more
wiley +1 more source
The role of Grafting in Canal Wall down Mastoidectomy Comparative Study [PDF]
Zagazig University Medical JournalBackground: Radical mastoidectomy is the outstanding standard technique for management of cholesteatoma. Long term studies showed increasing incidence of discharging cavities .
essam mohammed +2 more
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Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation. [PDF]
PLoS ONE, 2013 Epidermal squamous cell carcinoma is among the most common cancers in humans. These tumors are comprised of phenotypically diverse populations of cells that display varying potential for proliferation and differentiation. An important goal is identifying
Gautam Adhikary +11 more
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