Results 181 to 190 of about 5,007,843 (284)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Downregulation of KRTAP2‐3 Suppresses Proliferation and Tumor Formation of Oral Cancer Cells via Inactivation of KRAS Signals

Cancer Science, EarlyView.
KRTAP2‐3 drives OSCC progression by sustaining both mesenchymal and proliferative properties through KRAS signaling. Loss of KRTAP2‐3 induces MET, suppresses KRAS pathway activation, and markedly reduces tumor cell proiferation and tumor formation as illustarted in Figure.
Qianqian Miao, Zhijun Huang, Kazuki Takahashi, Haruka Ibi, Kohei Miyazono, Katarzyna A. Podyma‐Inoue, Tetsuro Watabe   +6 more
wiley   +1 more source

Mitochondrial Morphology Dynamics Remodel Metabolism and Affect TKI Sensitivity in EGFR‐Mutated Lung Cancer

Cancer Science, EarlyView.
TKI treatment promotes mitochondrial fission and metabolic reprogramming toward oxidative phosphorylation in residual EGFR‐mutant lung cancer cells. Targeting this metabolic vulnerability restores TKI sensitivity and provides a promising strategy to overcome acquired resistance.
Yu Zhao, Yuqiang Liu, Mingxuan Xie, Zhiming Ye, Hong Huang, Maojin Yao, Feng Zhou, Jianzhu Zhao, Jun Tang   +8 more
wiley   +1 more source

Itgb1‐Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress‐Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1‐Parkin‐Dependent Mitophagy

Cell Proliferation, EarlyView.
Excessive mechanical stress induces nucleus pulposus cell pyroptosis and intervertebral disc degeneration. Itgb1 inhibits MNAT1‐mediated ubiquitination and degradation of Vimentin. Vimentin alleviates excessive mechanical stress‐induced nucleus pulposus cell pyroptosis and intervertebral disc degeneration through PINK1‐Parkin‐dependent mitophagy ...
Xuening Liu, Fengguang Yang, Yanni Duan, Hefang Xiao, Zhenyu Cao, Zhaoheng Wang, Haijun Zhang, Xuewen Kang   +7 more
wiley   +1 more source

Identification of keratin 19-positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21-1. [PDF]

Cancer Med, 2017
Kawai T, Yasuchika K, Ishii T, Katayama H, Yoshitoshi EY, Ogiso S, Minami T, Miyauchi Y, Kojima H, Yamaoka R, Kita S, Yasuda K, Sasaki N, Fukumitsu K, Hatano E, Uemoto S.   +15 more
europepmc   +1 more source

AI‐Assisted Fungal Detection in Dermatopathology: A Study on Accuracy, Efficiency, and Usability

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives AI‐based image analysis is increasingly applied in pathology. Excluding fungal elements in PAS‐stained skin sections is labor‐intensive and well suited for AI assistance. While fungal detection in nails has been studied, skin‐biopsy applications and real‐world benefit remain limited.
Paul Schmidle, Tobias Lang, Sebastian Springenberg, Diego Calvopiña, Theresa Köhler, Valentina Getova, Ana‐Maria Gebing, Sonja Hetzer, Johanna Pierrone, Valentin Aebischer, Dieter Metze, Almut Böer‐Auer, Stephan Alexander Braun   +12 more
wiley   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Keratin 19 as a key molecule in progression of human hepatocellular carcinomas through invasion and angiogenesis. [PDF]

BMC Cancer, 2016
Takano M, Shimada K, Fujii T, Morita K, Takeda M, Nakajima Y, Nonomura A, Konishi N, Obayashi C.   +8 more
europepmc   +1 more source

Hepatic Carcinoma With Epithelial–Myoepithelial Differentiation and Metachronous Intrahepatic Recurrence Following Curative Resection: A Rare Case Report

Hepatology Research, EarlyView.
ABSTRACT Background and Aim Epithelial‐myoepithelial carcinoma (EMC), a malignant tumor with biphasic epithelial and myoepithelial differentiation, is typically a salivary gland neoplasm. Contrastingly, myoepithelial carcinoma (MEC) predominantly comprises myoepithelial cells.
Ryo Nagao, Tomoyuki Abe, Masateru Yamamoto, Yuki Imaoka, Naruhiko Honmyo, Seiichi Shimizu, Shintaro Kuroda, Hiroyuki Tahara, Masahiro Ohira, Kentaro Ide, Tsuyoshi Kobayashi, Tetsuya Nakagiri, Koji Arihiro, Hideki Ohdan   +13 more
wiley   +1 more source

A novel all‐in‐one dynamic wrinkle evaluation system: Development, validation and application in cosmetic industries

International Journal of Cosmetic Science, EarlyView.
Photo grading of dynamic lines in the dynamic line repeatability validation study. Abstract Objective This study aimed to develop and validate a novel, integrated dynamic wrinkle assessment system based on standardized, real‐time and multi‐angle facial images and video recordings, and to explore its potential application in evaluating the anti‐wrinkle ...
Xingzuo Liu, Juanjuan Chen, Chengda Ye, Andrew Steel, Yidong Tu, Frederic Flament, Jing Li   +6 more
wiley   +1 more source