Results 161 to 170 of about 74,447 (392)

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

open access: yesCytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

Rapid and Effective Determination of Ethyl Glucuronide in Hair by Micro Extraction by Packed Sorbent (MEPS) and LC‐MS/MS

open access: yesDrug Testing and Analysis, EarlyView.
The development and validation of a MEPS method for the purification of hair extract for the EtG determination and quantification in the keratin matrix is the main focus of this study. The method is fast and effective and, as a miniaturised technique, requires only small amounts of solvent.
Sara Odoardi   +4 more
wiley   +1 more source

Rapid and Simple Dispersive Liquid–Liquid Microextraction (DLLME) Sample Preparation for Propofol Analysis in Hair, Blood, and Urine by Gas Chromatography–Mass Spectrometry

open access: yesDrug Testing and Analysis, EarlyView.
Development and validation of an extraction method based on dispersive liquid–liquid microextraction for the analysis by GC–MS of propofol in three different biological samples (blood, urine, and hair). The proposed method is very simple and rapid.
Sara Odoardi   +4 more
wiley   +1 more source

Infant Death due to Cannabis Ingestion

open access: yesDrug Testing and Analysis, EarlyView.
ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto   +9 more
wiley   +1 more source

Long‐Term Stability of Ethyl Glucuronide in Hair: A 10‐Year Retrospective Analysis of 909 Samples by LC–MS/MS

open access: yesDrug Testing and Analysis, EarlyView.
EtG hair analysis has a standard method for detecting alcohol abuse. In this study, we assessed the long‐term stability of EtG in hair stored up to 10 years. A total of 909 samples originally analyzed between 2013 and 2022 were re‐tested in 2023 by LC‐MS/MS.
Sara Casati   +6 more
wiley   +1 more source

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez   +4 more
wiley   +1 more source

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