Results 191 to 200 of about 19,974 (294)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Spatial control of Keratin 8 phosphorylation by Aurora B facilitates cytokinesis in cancer cells of epithelial origin. [PDF]

FEBS J
Harmanda B, Ayaydin H, Waide X, Qureshi MH, Basrur V, Nesvizhskii AI, Mitchison TJ, Ozlu N.   +7 more
europepmc   +1 more source

Downregulation of KRTAP2‐3 Suppresses Proliferation and Tumor Formation of Oral Cancer Cells via Inactivation of KRAS Signals

Cancer Science, EarlyView.
KRTAP2‐3 drives OSCC progression by sustaining both mesenchymal and proliferative properties through KRAS signaling. Loss of KRTAP2‐3 induces MET, suppresses KRAS pathway activation, and markedly reduces tumor cell proiferation and tumor formation as illustarted in Figure.
Qianqian Miao, Zhijun Huang, Kazuki Takahashi, Haruka Ibi, Kohei Miyazono, Katarzyna A. Podyma‐Inoue, Tetsuro Watabe   +6 more
wiley   +1 more source

Keratin adducts in human hair prove exposure to sulfur mustard in a real case of poisoning and indicate exposure to sesquimustard and O-lost in vitro. [PDF]

Arch Toxicol
John H, Schmeißer W, Dentzel M, Steinritz D, Sezigen S, Worek F.   +5 more
europepmc   +1 more source

Follicular Keratinization

Journal of Investigative Dermatology, 1974
openaire   +2 more sources

Protein Corona‐Coated Crystal Silica From Sandstorms Amplifies Allergic Rhinitis by Regulating Epithelial Integrity in Mice and Human Nasal Epithelia

Allergy, EarlyView.
Cuishuang Dong, Xu Zhang, Haoyue Wang, Jiajing Cui, Shuai Han, Yibo Wang, Huanying Zhao, Yang Song, Yuan Zhang, Xiaobo Li   +9 more
wiley   +1 more source

Mitochondrial Morphology Dynamics Remodel Metabolism and Affect TKI Sensitivity in EGFR‐Mutated Lung Cancer

Cancer Science, EarlyView.
TKI treatment promotes mitochondrial fission and metabolic reprogramming toward oxidative phosphorylation in residual EGFR‐mutant lung cancer cells. Targeting this metabolic vulnerability restores TKI sensitivity and provides a promising strategy to overcome acquired resistance.
Yu Zhao, Yuqiang Liu, Mingxuan Xie, Zhiming Ye, Hong Huang, Maojin Yao, Feng Zhou, Jianzhu Zhao, Jun Tang   +8 more
wiley   +1 more source

Immunoreactivity for CD34, Desmin, Keratins, KIT, Alpha-Smooth Muscle Actin, S100, and Vimentin in Malignant Mesenchymal Neoplasms in Guinea Pigs: A Series of 62 Cases From a Single Institution. [PDF]

Vet Med Sci
Lenz J, Škorič M, Tichý F, Fiala L.
europepmc   +1 more source

The plasticisation model of dye diffusion: Part 7

Coloration Technology, EarlyView.
Abstract Re‐evaluation using the Williams‐Landel‐Ferry equation, of exhaustion/fixation/adsorption data previously reported for four classes of anionic dye onto three different types of wool substrate, revealed that thermally activated dyeing/desorption behaviour is governed by the thermally regulated structural relaxation times of the respective water‐
Stephen M. Burkinshaw
wiley   +1 more source

Primary Localized Cutaneous Amyloidosis: A Histological and Immunohistochemical Appraisal. [PDF]

Indian Dermatol Online J
Parvathy N, Joshi R, Bhattacharjee R, Saikia UN, De D, Chatterjee D.   +5 more
europepmc   +1 more source