Results 81 to 90 of about 7,935 (200)

Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications

open access: yesTherapeutics and Clinical Risk Management, 2014
Timothy Y Chou, Bennett Y Hong Department of Ophthalmology, Stony Brook University, Stony Brook, NY, USA Abstract: Eye disease due to herpes simplex virus (HSV) is a leading cause of ocular morbidity and the number one infectious cause of unilateral ...
Chou TY, Hong BY
doaj  

Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis

open access: yesClinical Ophthalmology, 2020
Kuo-Hsuan Hung,1– 3 Yu-Hsiang Lan,2,4 Jui-Yen Lin,1,2 Eugene Yu-Chuan Kang,1,2 Hsin-Yuan Tan,1,2 Hung-Chi Chen,1,2 Ching-Hsi Hsiao,1,2 Lung-Kun Yeh1,2 1Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan, 333, Taiwan; 2Chang ...
Hung KH   +7 more
doaj  

Expression of dectin-1 during fungus infection in human corneal epithelial cells

open access: yesInternational Journal of Ophthalmology, 2014
AIM:To evaluate the expression of dendritic cell-associated C-type lectin-1 (dectin-1) in human corneal epithelial (HCE) cells infected by fungus.METHODS:A total of 20 cases of healthy donor corneas were group A, and 20 patients (20 eyes) suffered from ...
Cui Li   +8 more
doaj   +1 more source

Ex vivo model of herpes simplex virus type I dendritic and geographic keratitis using a corneal active storage machine.

open access: yesPLoS ONE, 2020
BackgroundHerpetic keratitis (HK) models using whole human corneas are essential for studying virus-host relationships, because of high species specificity and the role of interactions between corneal cell populations that cell culture cannot reproduce ...
Emilie Courrier   +14 more
doaj   +1 more source

The development of drugs against Acanthamoeba infections [PDF]

open access: yes, 2016
For the past several decades, there has been little improvement in the morbidity and mortality associated with Acanthamoeba keratitis and Acanthamoeba encephalitis, respectively.
Aqeel, Yousuf   +2 more
core   +1 more source

Integrated genomics reveals cellular senescence‐driven molecular networks and immune crosstalk in myopia pathogenesis

open access: yesJournal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
This study identifies Tp53, Cdkn1a, and Myc as core senescence‐associated regulators driving myopia via immune and apoptotic pathways. Multi‐omics integration and in vivo validation reveal that these genes modulate ocular structure and apoptosis through the NF‐κB axis, highlighting a senescence–immune interplay as a potential therapeutic target in ...
Wangming Su   +4 more
wiley   +1 more source

Monkeypox-related ophthalmic disease

open access: yesTaiwan Journal of Ophthalmology
Monkeypox (Mpox) is an acute febrile rash illness caused by the Mpox virus. The ongoing international outbreak since mid-2022 has spread worldwide, including Taiwan.
Liang Yi-Ting   +4 more
doaj   +1 more source

Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty

open access: yesJournal of Ophthalmology, 2018
Purpose. To observe clinical characteristics and treatment outcomes of new onset herpes simplex keratitis (HSK) after keratoplasty. Methods. Among 1,443 patients (1,443 eyes) who underwent keratoplasty (excluding cases of primary HSK) in Shandong Eye ...
Xiaolin Qi   +6 more
doaj   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

open access: yesAdvanced Biology, Volume 9, Issue 7, July 2025.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim   +3 more
wiley   +1 more source

Features of the course of primary and recurrent herpetic keratitis developing following COVID-19 vaccination

open access: yesJournal of Ophthalmology
Purpose: To assess the features of the course of primary and recurrent herpetic keratitis (HK) developing following COVID-19 vaccination. Material and Methods: Medical records of 31 patients (34 eyes) with post-COVID-19 vaccination HK were reviewed ...
K.V. Sereda   +2 more
doaj   +1 more source

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