Results 21 to 30 of about 39,767 (260)

Keratoconus International Consortium (KIC)- advancing keratoconus research

open access: yesBMC Ophthalmology, 2023
Abstract Clinical relevance The Keratoconus International Consortium (KIC) will allow better understanding of keratoconus. Background Keratoconus is a disorder characterised by corneal elevation and thinning, leading to reduced vision.
Srujana Sahebjada   +36 more
openaire   +4 more sources

Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis

open access: yesCell Discovery, 2022
Keratoconus is a common ectatic corneal disorder in adolescents and young adults that can lead to progressive visual impairment or even legal blindness. Despite the high prevalence, its etiology is not fully understood. In this study, we performed single-
Shengqian Dou   +13 more
doaj   +1 more source

The variability of corneal and anterior segment parameters in keratoconus [PDF]

open access: yes, 2016
Purpose: To analyse, describe and test diverse corneal and anterior segment parameters in normal and keratoconic eyes to better understand the geometry of the keratoconic cornea. Method: 44 eyes from 44 keratoconic patients and 44 eyes from 44 healthy
Cardona Torradeflot, Genís   +3 more
core   +1 more source

Keratoconus epidemiology

open access: yesSaudi Journal of Ophthalmology, 2022
Keratoconus is an ectatic corneal disease that affects both men and women, usually at a young age. Risk factors such as eye rubbing, environmental and genetic factors contribute to its pathogenesis. Keratoconus presents a variable prevalence, being as high as 5% of the population in the Middle East.
Gomes, José A. P.   +2 more
openaire   +2 more sources

Prevalence and risk factors of keratoconus (including oxidative stress biomarkers) in a cohort study of Shiraz university of medical science employees in Iran

open access: yesBMC Ophthalmology, 2023
Background To determine the prevalence of keratoconus in Shiraz University of Medical Sciences Employees and the related risk factors including oxidative stress biomarkers. Methods 2546 subjects’ mean age ± SD, 40.35 ± 6.70 (46% male) were recruited. All
Sahar Mohaghegh   +7 more
doaj   +1 more source

Quantitative comparison of corneal surface areas in keratoconus and normal eyes

open access: yesScientific Reports, 2021
Keratoconus is a highly prevalent corneal disorder characterized by progressive corneal thinning, steepening and irregular astigmatism. To date, pathophysiology of keratoconus development and progression remains debated. In this study, we retrospectively
François-Xavier Crahay   +5 more
doaj   +1 more source

Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature [PDF]

open access: yes, 2016
Collagen cross-linking (CXL) is a relatively new conservative approach for progressive corneal ectasia, which is able to strengthen corneal tissue reforming new covalent bonds.
SPADEA, LEOPOLDO   +2 more
core   +1 more source

Rare single nucleotide variants in COL5A1 promoter do not play a major role in keratoconus susceptibility associated with rs1536482

open access: yesBMC Ophthalmology, 2021
Background Keratoconus is a chronic degenerative disorder of the cornea characterized by thinning and cone-shaped protrusions. Although genetic factors play a key role in keratoconus development, the etiology is still under investigation.
Liubov O. Skorodumova   +13 more
doaj   +1 more source

Prevalence of keratoconus in persons with Down syndrome: a review

open access: yesBMJ Open Ophthalmology, 2021
Purpose Keratoconus is a vision-threatening condition, and there is a need for knowledge about the occurrence in subgroups of the population. The progression of the disease can be effectively stopped, and vision may be restored, if keratoconus is ...
Liv Drolsum, Olav Kristianslund
doaj   +1 more source

Keratoconus

open access: yesCornea, 1988
Keratoconus is a bilateral disorder of corneal shape which may be sporadic or genetically determined. Early corneal thinning suggests that a functional loss of structural elements is a primary event in the disease. Tensile strength of the cornea is reduced and is expressed by signs of rupture and scarring in Bowman's layer, scarring in the substantia ...
William E. Smiddy   +3 more
openaire   +4 more sources

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