Non-invasive detection of nanoscale structural changes in cornea associated with cross-linking treatment [PDF]
, 2020 Corneal cross-linking (CXL) using UVA irradiation with a riboflavin photosensitizer has grown from an interesting concept to a practical clinical treatment for corneal ectatic diseases globally, such as keratoconus. To characterize the corneal structural changes, existing methods such as X-ray microscopy, transmission electron microscopy (TEM ...
arxiv +1 more source
SmartKC: Smartphone-based Corneal Topographer for Keratoconus Detection [PDF]
arXiv, 2021 Keratoconus is a severe eye disease affecting the cornea (the clear, dome-shaped outer surface of the eye), causing it to become thin and develop a conical bulge. The diagnosis of keratoconus requires sophisticated ophthalmic devices which are non-portable and very expensive.
arxiv
Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography [PDF]
arXiv, 2023 Collagen crosslinking of the cornea (CXL) is commonly employed to prevent or treat keratoconus. Although the change of corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic Optical Coherence Elastography (OCE) by tracking mechanical wave propagation, the depth dependence of this change is still unclear if the cornea is not ...
arxiv +1 more source
Corneal elevation and keratoconus indices in a 40- to 64-year-old population, Shahroud Eye Study
Journal of Current Ophthalmology, 2015 Purpose: To determine the corneal elevation values and keratoconus indices in the 40- to 64-year-old population and their changes with aging. Methods: The 6311 invitees of this study were selected through random cluster sampling, and 5190 of them ...
Hassan Hashemi +7 more
doaj +1 more source
Corneal endothelial cells changes in different stages of Keratoconus: a multi-Centre clinical study
BMC Ophthalmology, 2021 Purpose To assess the corneal endothelial cells morphology and count in keratoconus patients and their correlation with different stages of keratoconus. Methods Prospective non randomized multi-centric clinical study included 150 eyes of 150 keratoconus ...
Ahmed Elmassry +6 more
doaj +1 more source
Multiscale mechanical model based on patient-specific geometry: application to early keratoconus development [PDF]
arXiv, 2021 Keratoconus is a pathology of the cornea associated with a tissue thinning and a weakening of its mechanical properties. However, it remains elusive which aspect is the leading cause of the disease. To investigate this question, we combined a multiscale model with a patient-geometry in order to simulate the mechanical response of healthy and ...
arxiv
Keratoconus enlargement as a predictor of keratoconus progression
Scientific Reports, 2021 Numerous approaches have been designated to document progression in keratoconus, nevertheless there is no consistent or clear definition of ectasia progression.
Ana Maria Cunha +6 more
doaj +1 more source
A discrete-to-continuum model for the human cornea with application to keratoconus [PDF]
arXiv, 2023 We introduce a discrete mathematical model for the mechanical behaviour of a planar slice of human corneal tissue, in equilibrium under the action of physiological intraocular pressure (IOP). The model considers a regular (two-dimensional) network of structural elements mimicking a discrete number of parallel collagen lamellae connected by proteoglycan-
arxiv
Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
Advanced Biology, EarlyView.This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim +3 more
wiley +1 more source
Association between Corneal Stiffness Parameter at the First Applanation and Keratoconus Severity
Journal of Ophthalmology, 2020 Objective. The study aimed to evaluate the character of corneal stiffness parameter at the first applanation (SP-A1) in normal and keratoconus eyes and explore the association between SP-A1 and keratoconus severity indicators. Methods.
Kaili Yang +3 more
doaj +1 more source