Results 51 to 60 of about 1,347 (192)

Ineffectiveness of tumor necrosis factor-α blockers and ustekinumab in a case of type IV pityriasis rubra pilaris

Indian Dermatology Online Journal, 2015
Treatment of pityriasis rubra pilaris (PRP) may be difficult since no standardized therapeutic approach has been established. Recently, tumor necrosis factor-α (TNF-α) blockers have been demonstrated to be favorable in the management of recalcitrant PRP.
Vito Di Lernia, Elena Ficarelli, Magda Zanelli   +2 more
doaj   +1 more source

Applicability of Novel Laser Scanning Microscopy Techniques in Demonstrating Characteristic Features of Porokeratosis: In Vivo and Ex Vivo Investigation

JEADV Clinical Practice, Volume 5, Issue 1, Page 91-100, March 2026.
Porokeratoses, used here as an example of keratinization disorders, are marked by cornoid lamella and linked to skin cancer risk, making accurate diagnosis essential. This study compared conventional methods, dermoscopy, and histopathology, with advanced imaging using reflectance confocal microscopy (RCM) and multiphoton microscopy (MPM).
Rahime Inci, Noora Neittaanmäki, Jeemol James, Marica B. Ericson, Sirkku Peltonen, Despoina Kantere   +5 more
wiley   +1 more source

Papillon-Lefevre syndrome: A case report with review of literature

Journal of Indian Academy of Oral Medicine and Radiology, 2009
Papillon-Lefèvre syndrome is an extremely rare genodermatosis inherited as an autosomal recessive trait, affecting children between the ages of 1-4 years. It has a prevalence of 1-4 cases per million persons.
Rajeev Gadgil, Ajay Bhoosreddy, Varun Gul Bhatia   +2 more
doaj   +1 more source

Erythrokeratodermia‐Cardiomyopathy Syndrome: Expanding the DSP Mutational Spectrum Beyond Proline Substitutions

Pediatric Dermatology, Volume 43, Issue 2, Page 444-447, March/April 2026.
ABSTRACT Erythrokeratodermia cardiomyopathy (EKC) syndrome is a rare autosomal dominant disorder characterized by generalized erythrokeratoderma and progressive dilated cardiomyopathy, caused by pathogenic variants in the SR6 domain of desmoplakin (DSP).
Sepideh Hamzehlou, Ryland D. Mortlock, Caroline Echeandia‐Francis, Jing Zhou, Chao Xing, Nnenna G. Agim, Keith A. Choate, Donald A. Glass II   +7 more
wiley   +1 more source

Molecular insights into nagashima-type palmoplantar keratoderma: SERPINB7 mutation spectrum and mechanistic perspectives

Frontiers in Molecular Biosciences
Nagashima-type palmoplantar keratoderma (NPPK) is a common inherited palmoplantar keratoderma predominantly affecting East Asian populations and caused by biallelic loss-of-function variants in the SERPINB7 gene.
Zhenzhen Xiao, Yue Kang, Rui Li, Yingjian Tan   +3 more
doaj   +1 more source

Disseminated punctate keratoderma: a rare case report and review of the literature [PDF]

, 2017
We report a rare case of a 53-year-old womanpresenting with diffuse, late-onset disseminatedhyperkeratotic papules. Biopsy showed massivehyperkeratosis overlying a crateriform epidermaldepression and hypergranulosis with mild epidermalhyperplasia.
Asemota, Eseosa, Markova, Alina, Ho, Jonathan, Lichtman, Michael K   +3 more
core   +1 more source

Mal de Meleda: relato de 2 casos de ocorrência familiar Mal de Meleda: a report of two cases of familial occurrence

Anais Brasileiros de Dermatologia, 2011
Mal de Meleda é uma ceratodermia palmoplantar transgressiva rara, com prevalência estimada de 1:100.000 habitantes, descrita em 1826 por Stulli, na Ilha de Meleda.
Fernanda Ayres de Morais e Silva, Thiago Vinicius Ribeiro da Cunha, Elisangela dos Santos Boeno, Denise Steiner   +3 more
doaj   +1 more source

Gene for Arrhythmogenic Right Ventricular Cardiomyopathy With Diffuse Nonepidermolytic Palmoplantar Keratoderma and Woolly Hair (Naxos Disease) Maps to 17q21 [PDF]

Circulation, 1998
Background —Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease of unknown etiology that causes arrhythmias, heart failure, and sudden death. Diagnosis can be difficult, and this hampers investigation of its molecular basis.
A S, Coonar, N, Protonotarios, A, Tsatsopoulou, E W, Needham, R S, Houlston, S, Cliff, M I, Otter, V A, Murday, R K, Mattu, W J, McKenna   +9 more
openaire   +2 more sources

Review of Biological Agents in the Therapeutic Management of Monogenic Genodermatoses

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Monogenic genodermatoses encompass a diverse group of over 400 distinct disorders, presenting significant therapeutic challenges. Recent advancements in the clinical application of biological agents have heralded a new era in the management of these conditions.
Xueying Wang, Qing Zhao, Hong Liu, Furen Zhang, Zhiqiang Song   +4 more
wiley   +1 more source

Mycosis Fungoides in Pediatric Patients Revealed by Recalcitrant Psoriasiform Palmoplantar Keratoderma

JEADV Clinical Practice, Volume 4, Issue 5, Page 1202-1206, December 2025.
ABSTRACT Mycosis fungoides is a cutaneous T‐cell lymphoma with a classically relatively good prognosis, mostly diagnosed in men over the age of 50. It classically manifests as erythematosquamous plaques, but can take a variety of forms. Here we describe four cases of mycosis fungoides diagnosed in children, with psoriasiform palmoplantar keratoderma as
S. Grandjacquot, C. Ram‐Wolff, A. De Masson, P. Drabent, S. Fraitag, P. Bataille, M. Battistella, E. Bourrat   +7 more
wiley   +1 more source