Results 121 to 130 of about 3,324 (167)
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NeoReviews, 2023
Kernicterus is the potential toxic sequela of extreme neonatal hyperbilirubinemia resulting from the passage of excess free, unconjugated bilirubin across the blood−brain barrier, irreversibly and selectively damaging vulnerable target brain cells including the basal ganglia, the cerebellum, and the auditory system.
Yair, Kasirer +2 more
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Kernicterus is the potential toxic sequela of extreme neonatal hyperbilirubinemia resulting from the passage of excess free, unconjugated bilirubin across the blood−brain barrier, irreversibly and selectively damaging vulnerable target brain cells including the basal ganglia, the cerebellum, and the auditory system.
Yair, Kasirer +2 more
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The pathochemistry of kernicterus
Early Human Development, 1979The stoichiometry of bilirubin--albumin interaction has been analyzed and quantitated in several recent studies, confirming that albumin binding of bilirubin obeys the law of mass action [4, 5, 14, 16, 26, 36, 43, 46, 61, 65, 73, 92, 111]. These studies provide a basis for interpreting bilirubin transport, cell uptake and toxicity from physicochemical ...
R P, Wennberg +2 more
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Annals of Neurology, 1986
AbstractA 43‐year‐old woman was initially seen because of icterus. Clinical investigations revealed severe hepatic damage probably due to non‐A, non‐B hepatitis. She was treated with extracorporeal charcoal‐column perfusion but died two weeks later in a hepatic coma. At autopsy, the brain showed kernicterus with typical discoloration of the hippocampus,
M, Waser, P, Kleihues, P, Frick
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AbstractA 43‐year‐old woman was initially seen because of icterus. Clinical investigations revealed severe hepatic damage probably due to non‐A, non‐B hepatitis. She was treated with extracorporeal charcoal‐column perfusion but died two weeks later in a hepatic coma. At autopsy, the brain showed kernicterus with typical discoloration of the hippocampus,
M, Waser, P, Kleihues, P, Frick
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Australasian Radiology, 2003
SUMMARYKernicterus (bilirubin encephalopathy) is a disease entity with a very high rate of mortality in neonates. The children who survive are left with neurological deficits such as choreoathetosis, sensorineural deafness and mental retardation. Magnetic resonance imaging of the brain in this condition has specfic findings which aid in the accurate ...
Zarine, Shah +3 more
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SUMMARYKernicterus (bilirubin encephalopathy) is a disease entity with a very high rate of mortality in neonates. The children who survive are left with neurological deficits such as choreoathetosis, sensorineural deafness and mental retardation. Magnetic resonance imaging of the brain in this condition has specfic findings which aid in the accurate ...
Zarine, Shah +3 more
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Pediatrics, 1983
To the Editor.— Turkel and associates1 postulate that gross bilirubin staining of newborn infants' brains, as observed at autopsy, is only incidental and does not correlate with specific microscopic changes as described with "true kernicterus": microscopic study of brain sections from 32 infants in whom the typical gross bilirubin ...
M, Ahdab-Barmada, J, Moossy
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To the Editor.— Turkel and associates1 postulate that gross bilirubin staining of newborn infants' brains, as observed at autopsy, is only incidental and does not correlate with specific microscopic changes as described with "true kernicterus": microscopic study of brain sections from 32 infants in whom the typical gross bilirubin ...
M, Ahdab-Barmada, J, Moossy
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Hyperbilirubinemia and Kernicterus
Clinics in Perinatology, 2006This article describes new findings concerning the basic science of bilirubin neurotoxicity, new considerations of the definition of clinical kernicterus, and new and useful tools to diagnose kernicterus in older children, and discusses treatments for kernicterus beyond the newborn period and why proper diagnosis is important.
Steven M, Shapiro +2 more
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Archives of Otolaryngology - Head and Neck Surgery, 1950
The most dreaded late complication of hemorrhagic disease of the newborn (erythroblastosis fetalis) is kernicterus. This is manifest pathologically as more or less symmetrical yellow pigmentation of the basal ganglions and certain brain nuclei associated with severe cell damage and clinically as motor abnormalities and varying degrees of permanent ...
R N, BARNETT, C F, RYDER
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The most dreaded late complication of hemorrhagic disease of the newborn (erythroblastosis fetalis) is kernicterus. This is manifest pathologically as more or less symmetrical yellow pigmentation of the basal ganglions and certain brain nuclei associated with severe cell damage and clinically as motor abnormalities and varying degrees of permanent ...
R N, BARNETT, C F, RYDER
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A.M.A. Archives of Neurology & Psychiatry, 1955
The term "kernicterus" was coined by Schmorl,1who in 1903 reported observations of bile staining in the basal ganglia, cerebellum, and brain stem in the newborn infant with jaundice, similar to those recorded by Orth2in 1875. In 1932 Diamond, Blackfan, and Baty3considered anemia, hydrops fœtalis, and icterus gravis to be manifestations of ...
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The term "kernicterus" was coined by Schmorl,1who in 1903 reported observations of bile staining in the basal ganglia, cerebellum, and brain stem in the newborn infant with jaundice, similar to those recorded by Orth2in 1875. In 1932 Diamond, Blackfan, and Baty3considered anemia, hydrops fœtalis, and icterus gravis to be manifestations of ...
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American Journal of Diseases of Children, 1947
WITH the advent of more detailed knowledge concerning the pathogenesis and treatment of erythroblastosis fetalis, interest has been focused on the possible untoward effects of a successful therapeutic regimen that may result in a live but helpless infant with kernicterus.
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WITH the advent of more detailed knowledge concerning the pathogenesis and treatment of erythroblastosis fetalis, interest has been focused on the possible untoward effects of a successful therapeutic regimen that may result in a live but helpless infant with kernicterus.
openaire +1 more source