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NeoReviews, 2023
Kernicterus is the potential toxic sequela of extreme neonatal hyperbilirubinemia resulting from the passage of excess free, unconjugated bilirubin across the blood−brain barrier, irreversibly and selectively damaging vulnerable target brain cells including the basal ganglia, the cerebellum, and the auditory system.
Yair, Kasirer +2 more
openaire +3 more sources
Kernicterus is the potential toxic sequela of extreme neonatal hyperbilirubinemia resulting from the passage of excess free, unconjugated bilirubin across the blood−brain barrier, irreversibly and selectively damaging vulnerable target brain cells including the basal ganglia, the cerebellum, and the auditory system.
Yair, Kasirer +2 more
openaire +3 more sources
ACS Chemical Neuroscience, 2021
Kernicterus is a severe complication of extreme neonatal hyperbilirubinemia. Prolonged exposure to high-level unconjugated bilirubin (UCB) directly damages brain tissue. Neuroinflammation is believed to contribute to UCB-induced neurotoxicity. Pyroptosis
Siyu Li +9 more
semanticscholar +1 more source
Kernicterus is a severe complication of extreme neonatal hyperbilirubinemia. Prolonged exposure to high-level unconjugated bilirubin (UCB) directly damages brain tissue. Neuroinflammation is believed to contribute to UCB-induced neurotoxicity. Pyroptosis
Siyu Li +9 more
semanticscholar +1 more source
Neonatology, 2021
Background: Total serum bilirubin (TSB) is used in managing neonates with jaundice, but clear evidence on its association with major outcomes is lacking.
N. Lai +4 more
semanticscholar +1 more source
Background: Total serum bilirubin (TSB) is used in managing neonates with jaundice, but clear evidence on its association with major outcomes is lacking.
N. Lai +4 more
semanticscholar +1 more source
Journal of Maternal-Fetal & Neonatal Medicine, 2021
Background Hyperbilirubinemia is one of the most common diagnosis in newborn nurseries in United States. Universal pre-discharge bilirubin screening decreased the incidence of extreme hyperbilirubinemia and risk of kernicterus.
Ramesh Vidavalur, S. Devapatla
semanticscholar +1 more source
Background Hyperbilirubinemia is one of the most common diagnosis in newborn nurseries in United States. Universal pre-discharge bilirubin screening decreased the incidence of extreme hyperbilirubinemia and risk of kernicterus.
Ramesh Vidavalur, S. Devapatla
semanticscholar +1 more source
Hyperbilirubinemia and Kernicterus [PDF]
Clinics in Perinatology, 2006 This article describes new findings concerning the basic science of bilirubin neurotoxicity, new considerations of the definition of clinical kernicterus, and new and useful tools to diagnose kernicterus in older children, and discusses treatments for kernicterus beyond the newborn period and why proper diagnosis is important.
Steven M. Shapiro +2 more
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Trends in Hospitalization for Neonatal Jaundice and Kernicterus in the United States, 2006-2017
Section on Neonatal-Perinatal Medicine Program, 2021Background: The American Academy of Pediatrics reissued its guidelines on the management of jaundice in newborns born at ≥35 weeks gestation in 2004. The impact of this on the management of jaundice and the incidence of kernicterus in the United States ...
Abdul Wassay Khan +8 more
semanticscholar +1 more source
The pathochemistry of kernicterus
Early Human Development, 1979The stoichiometry of bilirubin--albumin interaction has been analyzed and quantitated in several recent studies, confirming that albumin binding of bilirubin obeys the law of mass action [4, 5, 14, 16, 26, 36, 43, 46, 61, 65, 73, 92, 111]. These studies provide a basis for interpreting bilirubin transport, cell uptake and toxicity from physicochemical ...
Charles E. Ahlfors +2 more
openaire +3 more sources
Combating the Hidden Health Disparity of Kernicterus in Black Infants: A Review.
JAMA pediatrics, 2020Importance Kernicterus is a devastating, permanently disabling neurologic condition resulting from bilirubin neurotoxicity. Black neonates account for more than 25% of kernicterus cases in the US, despite making up only approximately 14% of all births ...
F. Okolie, J. South-Paul, J. Watchko
semanticscholar +1 more source