Results 131 to 140 of about 174,609 (228)

Ketamine as an NMDA-modulating therapy in bipolar disorder: rationale and evidence. [PDF]

Front Psychiatry
Queissner R, Fellendorf F, Reininghaus EZ.   +2 more
europepmc   +1 more source

Modulation of the Stress Granule Component Carhsp1 Mitigates Disease‐Associated Deficits in Spinocerebellar Ataxia Type 3 Mouse Models

Movement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) neurogenerative disorder that results from CAG trinucleotide repeat expansions in the ATXN3 gene, leading to toxic protein aggregate formation and cellular pathway dysfunction.
Tiago Moreira‐Gomes, Adriana Marcelo, Ana Teresa Rajado, Rafael G. Costa, Ricardo Afonso‐Reis, Cristiana R. Madeira, Inês T. Afonso, David V.C. Brito, Adriana A. Vaz, Clévio Nóbrega   +9 more
wiley   +1 more source

Divergent Mechanisms of Antidepressant Efficacy: A Unified Computational Comparison of Synaptogenesis, Stabilization, and Tonic Inhibition in a Model of Depression. [PDF]

Cureus
Cheung N.
europepmc   +1 more source

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances, EarlyView.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting, Richard Evans Hartman   +1 more
wiley   +1 more source

Ketamine Use for ED Sedation: Pharmacologic Basis, Clinical Applications, and Safety Considerations. [PDF]

Cureus
Montoya S, Soto Cordero CA, Zamora EL, Chavarría R, Alvarez Ramirez D.   +4 more
europepmc   +1 more source

A Hybrid RF Coil for Whole‐Brain Imaging in Non‐Human Primates at 7 T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Ultra‐high field MRI (≥ 7 T) offers unprecedented potential for mapping non‐human primate (NHP) brain function. However, complex electromagnetic systems are required to meet the challenges of UHF imaging and the mechanical demands of awake NHP studies.
Elias Djaballah, Éric Giacomini, Paul‐François Gapais, Michel Luong, Alexis Amadon, Qi Zhu   +5 more
wiley   +1 more source

Sympathetic activation but not dissociation linked to ketamine's sustained antidepressant effect. [PDF]

Ther Adv Psychopharmacol
Andrashko V, Novak T, Kopecek M, Sulakova A, Knop V, Horacek J.   +5 more
europepmc   +1 more source

Age‐Dependent Correlation of Pulmonary Function Impairment and Aortic Arch Stiffness in Mice

Pediatric Discovery, EarlyView.
This study examined the relationship between aortic arch stiffness and lung function in aging mice. Multiple linear regression modeling showed moderate to strong correlations between the rise in aortic arch stiffness and changes in lung function as the mice progressively aged.
Ayman Isbatan, Samuel M. Lee, Ali Imran Sarwar, Yuxing Yuan, Sunny Chen, Maricela Castellon, Dan A. Marian, Richard D. Minshall, Jie Tian, Irena Levitan, Jiwang Chen   +10 more
wiley   +1 more source

Crosslinked Gelatin‐Polycaprolactone Scaffolds: Balancing Biocompatibility and Inflammatory Response for Tissue Engineering Applications

Polymer Engineering &Science, EarlyView.
Crosslinked gelatin‐functionalized PCL scaffolds exhibited enhanced hydrophilicity, structural stability, and porous interactions. In vitro assays demonstrated improved osteoblast adhesion, viability, and proliferation without cytotoxicity, while in vivo evaluation showed no adverse inflammatory response, supporting their potential application in ...
Fernanda Ramírez‐Ruiz, Israel Núñez‐Tapia, Lucía Pérez‐Sánchez, María Cristina Piña‐Barba, Irving Sanchez‐Leal, Marco Antonio Alvarez‐Perez, Iriczalli Cruz‐Maya, Janeth Serrano‐Bello   +7 more
wiley   +1 more source

Grayken lessons: a multidisciplinary approach to care for a patient with severe ketamine use disorder. [PDF]

Addict Sci Clin Pract
Appley M, Gray JR, Abdulrahim D, Bowden-Jones O.   +3 more
europepmc   +1 more source