Results 141 to 150 of about 290,727 (340)

Lupeol‐Loaded Liposomes: Triple‐Negative Breast Cancer (TNBC) Cytotoxicity and In Vivo Toxicological Evaluation

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Lupeol is a natural product commonly found in many vegetables and fruits in significant quantities. Previous studies have demonstrated the relevant activity of lupeol against various tumor cell lines, suggesting that the natural product could be a promising agent for cancer treatment.
Daniel Crístian Ferreira Soares   +6 more
wiley   +1 more source

Endothelium‐Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca2+ Channels

open access: yesChemistry &Biodiversity, EarlyView.
Involvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Martina Odebrecht Cavichiolo   +3 more
wiley   +1 more source

Increasing plasma ketamine concentrations decrease the minimum alveolar concentration of isoflurane in rabbits

open access: yesFrontiers in Veterinary Science
To evaluate the effects of increasing plasma ketamine concentration on isoflurane minimum alveolar concentration (MAC) in rabbits, six New Zealand white rabbits weighing 4.21 ± 0.35 kg were anesthetized with isoflurane in oxygen.
Linda S. Barter, Bruno H. Pypendop
doaj   +1 more source

Market Analysis of Synthetic Drugs: Amphetamine-type Stimulants, New Psychoactive Substances [PDF]

open access: yes, 2017
An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...

core  

Effects of Embryo Production Method and Culture Medium on Embryonic Development in Red‐Rumped Agouti

open access: yesCell Biology International, EarlyView.
ABSTRACT Advances in Assisted Reproductive Technologies (ARTs) help overcome reproductive barriers. However, a comprehensive understanding of embryonic development is crucial for their success. In vitro fertilization (IVF) and artificial oocyte activation (AOA) are embryo production methods commonly used.
Lhara Ricarliany Medeiros de Oliveira   +5 more
wiley   +1 more source

Ketamine for Refractory Headache: A Retrospective Analysis. [PDF]

open access: yes, 2018
BACKGROUND AND OBJECTIVES: The burden of chronic headache disorders in the United States is substantial. Some patients are treatment refractory. Ketamine, an N-methyl-D-aspartate antagonist, provides potent analgesia in subanesthetic doses in chronic ...
Dayan, Amir C.   +8 more
core   +1 more source

Rewriting Alkene Frameworks: A Practical Strategy for Nitrogen Incorporation

open access: yesChemistryEurope, EarlyView.
Morandi and team developed a metal‐free method to insert nitrogen into unactivated alkenes, forming amidines and nitriles via a transient aza‐allenium intermediate. Using mild, open‐flask conditions, the process delivers high yields and broad functional group tolerance.
Ranjini Laskar, Frank Glorius
wiley   +1 more source

Safety and Efficacy of the NMDA‐2b‐Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre   +9 more
wiley   +1 more source

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