Results 81 to 90 of about 235,967 (343)

Ketamine-induced uropathy

Continence
Ketamine induced uropathy has become a new bladder pain syndrome affecting the bladder, kidney, and quality of life in ketamine abusers. Ketamine-associated cystitis (KC) is an emerging public health concern, particularly among young adults who abuse ...
Hann-Chorng Kuo
doaj   +1 more source

Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Chronic Pain From the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists

Regional anesthesia and pain medicine, 2018
Background Over the past 2 decades, the use of intravenous ketamine infusions as a treatment for chronic pain has increased dramatically, with wide variation in patient selection, dosing, and monitoring.
Steven P. Cohen, A. Bhatia, A. Buvanendran, E. Schwenk, A. Wasan, R. Hurley, E. Viscusi, S. Narouze, Fred N. Davis, E. C. Ritchie, T. Lubenow, W. M. Hooten   +11 more
semanticscholar   +1 more source

The role of dissociation in ketamine’s antidepressant effects

Nature Communications, 2020
Ketamine produces immediate antidepressant effects and has inspired research into next-generation treatments. Ketamine also has short term dissociative effects, in which individuals report altered consciousness and perceptions of themselves and their ...
E. Ballard, C. Zarate
semanticscholar   +1 more source

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

Advanced Healthcare Materials, EarlyView.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer, Lea Skrzypczyk, Sabrina Wohlfart, Bryan Calder Ackermann, Ludwig Geisweid, Simon William Pohl, Margarita Karaivanova, Jonathan Herth, Victor Aristide Augustin, Alexander Studier‐Fischer, Tina Sackmann, Leon Kaulen, Anna Steyer, Walter Mier, David H Steel, Kanmin Xue, Gerd Uwe Auffarth, Philipp Uhl   +17 more
wiley   +1 more source

Guidelines for ketamine use in clinical psychiatry practice

BJPsych Open
In this editorial, we emphasise the efficacy and challenges of using ketamine in treatment-resistant depression. We highlight the need for comprehensive evidence-based guidelines to manage the use of both licensed and off-licence ketamine formulations ...
Luke A. Jelen, Rupert McShane, Allan H. Young   +2 more
doaj   +1 more source

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin

Neuropsychopharmacology, 2020
Twenty-four hours after administration, ketamine exerts rapid and robust antidepressant effects that are thought to be mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1).
C. Abdallah, L. Averill, R. Gueorguieva, Selin Goktas, P. Purohit, M. Ranganathan, M. Sherif, K. Ahn, D. D’Souza, R. Formica, S. Southwick, R. Duman, G. Sanacora, J. Krystal   +13 more
semanticscholar   +1 more source

Plasma‐Polymerized Nanoparticles Presenting Fibrillin‐1 Drive Rapid Re‐Endothelialization of Vascular Grafts

Advanced Healthcare Materials, EarlyView.
Commercial vascular grafts are made from ePTFE, a highly hydrophobic, foreign material that fails at a high rate in small‐diameter applications. Plasma polymer nanoparticles (PPN) are a versatile material functionalisation tool, used here to present fibrillin‐1 fragment PF8 on the graft surface.
Bob S. L. Lee, Yuen Ting Lam, Alex H. P. Chan, Praveesuda L. Michael, Timothy C. Mitchell, Jui Chien Hung, Miguel Santos, Khoon S. Lim, Richard P. Tan, Steven G. Wise   +9 more
wiley   +1 more source

Evaluation of the cardiorespiratory effects of the alpha-2 adrenoceptor agonists xylazine, medetomidine and dexmedetomidine in combination with ketamine in dogs

Veterinární Medicína, 2018
In this study, we compared the effects of xylazine, medetomidine and dexmedetomidine in combination with ketamine on heart rate, respiratory rate, blood gas values, temperature and sedation scores. A total of 30 dogs were evaluated.
O. Guzel, D.A. Kaya, K. Altunatmaz, G. Sevim, D. Sezer, D.O. Erdikmen   +5 more
doaj   +1 more source

Perioperative intravenous ketamine for acute postoperative pain in adults.

Cochrane Database of Systematic Reviews, 2018
BACKGROUND Inadequate pain management after surgery increases the risk of postoperative complications and may predispose for chronic postsurgical pain.
E. Brinck, E. Tiippana, M. Heesen, R. Bell, S. Straube, R. Moore, V. Kontinen   +6 more
semanticscholar   +1 more source

Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Ketamine, an NMDA receptor antagonist, has generated intense excitement as a therapy for treatment-resistant depression. However, ketamine and its metabolites can act on a wide range of targets, including opioid receptors, which has raised ...
Matthew E. Klein, Joshua Chandra, Salma A. Sheriff, R. Malinow   +3 more
semanticscholar   +1 more source