Results 81 to 90 of about 219,641 (298)

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Unique Effects of (R)-Ketamine Compared to (S)-Ketamine on EEG Theta Power in Rats

Pharmaceuticals
Differences in the pharmacological effects of (S)-ketamine and (R)-ketamine are at the focus of research. Clinical data and our rat studies confirmed the antidepressant effect of (S)- but not (R)-ketamine, with similar differences in quantitative ...
Dóra Pothorszki, Szabolcs Koncz, Dóra Török, Noémi Papp, György Bagdy   +4 more
doaj   +1 more source

Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration in Shetland ponies sedated with xylazine

, 2008
The pharmacokinetics of ketamine and norketamine enantiomers after administration of intravenous (IV) racemic ketamine (R-/S-ketamine; 2.2 mg/kg) or S-ketamine (1.1 mg/kg) to five ponies sedated with IV xylazine (1.1 mg/kg) were compared.
Kronen, Peter W, Larenza, M Paula, Levionnois, Olivier L, Knobloch, M, Landoni, M F, Landoni, M Fabiana, Thormann, Wolfgang, Larenza, M P, Knobloch, Monika, Theurillat, R, Schatzmann, U, Thormann, W, Schatzmann, Urs, Theurillat, Regula, Levionnois, O L, Kronen, Peter Wilhelm, Larenza, Maria-Paula, Levionnois, Olivier, Regula Theurillat, Monika Knobloch, Wolfgang Thormann, M. Fabiana Landoni, Peter W. Kronen, M. Paula Larenza, Urs Schatzmann, Olivier L. Levionnois   +25 more
core   +1 more source

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Decreased bone mineral density in ovariectomized mice is ameliorated after subsequent repeated intermittent administration of (R)‐ketamine, but not (S)‐ketamine

Neuropsychopharmacology Reports, 2020
Aim Depression is a common symptom in people with osteoporosis. (R)‐ketamine produced greater potency and longer‐lasting antidepressant‐like actions than (S)‐ketamine in rodents.
Yuko Fujita, Kenji Hashimoto
doaj   +1 more source

Ketamine Sedation of Case with Unknown Posterior Fossa Tumor [PDF]

, 2016
Ketamine, chosen for many years for anesthetic practice, is the only agent with analgesic, hypnotic and amnesic effects. Since the use of ketamine may cause uncontrolled increases in intracranial pressure, in the literature, there are concerns about its ...
Mehmet Akın, Gamze Küçükosman, Murat Çimencan, Hilal Ayoğlu, Dilek Okyay, Bengü Gülhan Aydın, Özcan Pişkin   +6 more
core   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Ketamine* [PDF]

Journal of Pain and Symptom Management, 2015
Rachel, Quibell, Marie, Fallon, Mary, Mihalyo, Robert, Twycross, Andrew, Wilcock   +4 more
openaire   +2 more sources

Ketamine-induced cell death is counteracted by PACAP via PAC-1 receptor activation.

, 2017
NSCs were plated as single cells. Cells were incubated with 400 μM ketamine and PACAP (100 nM) or agonist for PAC-1; Max-4 (30 nM). After 24 hour incubation, intracellular ATP levels were measured for cell viability.
Ingrid Agartz (378654), Sven-Ove Ögren (3709486), Shiva Mansouri (2838086), Mathias Lundberg (85855), Cesare Patrone (610978)   +4 more
core   +1 more source

The mechanism of labor in nonhuman primates: A look inside

The Anatomical Record, EarlyView.
Abstract While in humans, the flexed position of the fetus and its rotating course down the birth canal are well documented, in other primates the mechanism of labor is unknown. Despite the lack of comparative data, it is commonly assumed that the human obstetric mechanism is unique, and anthropologists have disputed when and why the transition to the ...
Melissa K. Stoller
wiley   +1 more source