Results 121 to 130 of about 54,503 (294)

Detecting and subtyping ketoacidosis from metabolomic patterns in forensic casework

Subtyping of ketoacidosis, a metabolic state characterized by blood acidification due to various causes, remains challenging in forensic casework. Postmortem omics samples paired with machine learning offer an independent tool to address this challenge ...
Green, Henrik, Magnusson, Rasmus, Monte, Ralph E. C., Soderberg, Carl, Elmsjo, Albert, Nyman, Elin, Magnusson, Rasmus,, Soderberg, Carl,, Green, Henrik,, Nyman, Elin,, Elmsjo, Albert,, Monte, Ralph E. C.,   +11 more
core   +1 more source

The Smart MDI System in People With Type 1 Diabetes and High HBA1C: A Randomized Controlled Trial Demonstrating That Response to Alerts Drives Outcomes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The aim was to assess the efficacy and safety of the smart multiple daily injections (MDI) system versus MDI plus continuous glucose monitor (CGM) in people with Type 1 diabetes and HbA1c ≥ 8%. Material and Methods After a 3‐week run‐in, 143 participants were randomized to Smart MDI or MDI + CGM.
Laurent Crenier, Martin Haluzik, Marcus Lind, Pieter Gillard, Regis P. Radermecker, Angela Girelli, Jens Kroeger, Valeria Cosma, Francesco Giorgino, Charles Thivolet, Peter Adolfsson, Tobias Wiesner, Emmanuel Sonnet, Christophe de Block, Torben Biester, Helene Hanaire, Fabio di Piazza, Fabiona Hoevelaken, Renee Tillie, Tim van den Heuvel, Shannon Edd, Ohad Cohen   +21 more
wiley   +1 more source

Diabetic ketoacidosis: Should current management include subcutaneous insulin injections?

, 2017
Diabetic ketoacidosis is a well-known acute complication in patients with both type 1 and type 2 diabetes mellitus. Although mortality has decreased considerably, it remains an important cause for admission to intensive care units.
Hawa Edriss, Rocio Gavidia Quezada
core   +1 more source

Impact of DBLG1 Hybrid Closed‐Loop Software Optimization and Meal Declaration Pattern on Glucose Metrics in Type 1 Diabetes: A 12‐Month Prospective Evaluation in 2014 Users

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background The meal period is critical for the outcome of automated insulin delivery. Our aim was to explore the long‐term impact on glucose metrics of algorithmic modifications of the DBLG1 hybrid closed‐loop system, with special emphasis on the meal declaration pattern.
Pierre‐Yves Benhamou, Aurélien Vesin, Lucile Reynaud, Thibault Le Roux‐Mallouf, Benjamin Chatel   +4 more
wiley   +1 more source

Population‐Based Screening for Type 1 Diabetes in Czechia: Results From the First 1% of the Paediatric Population

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims EDENT1FI is a European initiative aiming to implement a roadmap for screening, monitoring and prevention of childhood Type 1 diabetes (T1D). The Betty project is a nationwide T1D screening program recently established in Czechia within the framework of EDENT1FI.
Barbora Berka, Ondřej Cinek, Vít Neuman, Klára Hubáčková, Agáta Čermáková, Andrea Radková, Samuel Owoeye, Maximilian Goetz, Florian Haupt, Peter Achenbach, Jurgen Vercauteren, Lutgart Overbergh, Chantal Mathieu, Anette‐Gabriele Ziegler, Zdeněk Šumník, on behalf of EDENT1FI Consortium, C. Mathieu, P. Gillard, K. Casteels, B. van der Schueren, L. Overbergh, J. Vercauteren, A. G. Ziegler, P. Achenbach, F. Haupt, C. Winkler, S. Hummel, F. Reschke, O. Kordonouri, T. von dem Berge, K. Lange, T. Pieber, J. Mader, S. Moitzi, S. Del Prato, B. Torbeyns, Z. Sumnik, O. Cinek, V. Neuman, B. Berka, F. Pociot, B. Petersen, J. Antvorskov, J. H. Klaebel, R. Lahesmaa, H. Hyöty, J. E. Laiho, E. Bonifacio, R. Berner, A. Hommel, A. Loff, G. Gemulla, N. Zubizarreta, E. Bosi, L. Piemonti, V. Lampasona, F. Dotta, G. Sebastiani, A. Szypowska, K. Karczewski, P. Jarosz‐Chobot, J. F. Raposo, R. Ribeiro, R. Coelho, M. Peakman, E. Niemoeller, M. Baccara‐Dinet, J. Van Rampelbergh, R. Bergholdt, K. Fogh, C. Hurtado del Pozo, E. Latres, G. Agiostratidou, A. KoralovaJ. Jackson, D. Darrock, H. Tewson, S. Nagallas, J. Hedrick, K. Collins, T. Tree, C. Dayan, K. Hood, J. Townson, R. Playle, R. Besser, P. Narendran, I. Litchfield, S. Greenfield, R. Dias   +88 more
wiley   +1 more source

Closed‐Loop Insulin Delivery in Inpatient Care: A Systematic Review and Meta‐Analysis of Clinical and Implementation Outcomes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Closed‐loop (CL) insulin delivery systems have transformed outpatient diabetes care. However, evidence supporting their role in inpatient settings is limited. This systematic review and meta‐analysis evaluated the safety, efficacy, and implementation of CL systems in inpatient care.
Vaynika Gupta, Amanda Ling Jie Yee, Eleni Armeni, Kalyaani Persad, Aspasia Manta, Punith Kempegowda   +5 more
wiley   +1 more source

Diabetic Ketoacidosis: Systematic Review and Meta‐Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetic ketoacidosis (DKA) remains a major cause of diabetes‐related morbidity and mortality worldwide, yet evidence on its management and clinical outcomes across healthcare settings remains limited. We conducted a systematic review and meta‐analysis to evaluate the precipitants, management and outcomes of adult DKA.
Lucy A. Bomphrey, James French, Aspasia Manta, Kalyaani Persad, Katie Scandrett, Ketan Dhatariya, Punith Kempegowda   +6 more
wiley   +1 more source

Effect of sodium glucose cotransporter 2 inhibition immediately prior to heart transplantation

JHLT Open
Sodium glucose cotransporter 2 inhibitors (SGLT2i) are an established treatment for heart failure and type 2 diabetes. Guidelines suggest withholding SGLT2i preoperatively due to the risk of ketoacidosis.
Lisa M. Raven, MBBS, FRACP, Christopher A. Muir, MBBS (Hons), FRACP, PhD, Ricardo C. Deveza, MD, FRACP, Cassia Kessler Iglesias, MD (Hons), FRACP, Nicole K. Bart, MBBS (Hons), BSc (Med Sci), DPhil (Oxon), FRACP, Kavitha Muthiah, MBChB, PhD, FRACP, Eugene Kotlyar, MBBS, MD, MPVD, FRACP, Christopher S. Hayward, BMedSc, MBBS (Hons), MD, FRACP, Peter S. Macdonald, MBBS, MD, PhD, FRACP, Andrew Jabbour, BSc (Med), MBBS (Hons), PhD, FRACP, Jerry R. Greenfield, MBBS (Hons 1), PhD, FRACP   +10 more
doaj   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Recurrent diabetic ketoacidosis

Objective The purpose of this study is to examine risk factors for recurrence of diabetic ketoacidosis and determine interventions to prevent future admissions. Materials and methods Review article.
Carmi Bartal, Alan Jotkowitz, Leonid Barski, Evgenia Brandstaetter, Iftach Sagy   +4 more
core   +1 more source