Results 21 to 30 of about 24,707 (302)

Biochemical phenotyping unravels novel metabolic abnormalities and potential biomarkers associated with treatment of GLUT1 deficiency with ketogenic diet. [PDF]

PLoS ONE, 2017
Global metabolomic profiling offers novel opportunities for the discovery of biomarkers and for the elucidation of pathogenic mechanisms that might lead to the development of novel therapies.
Gerarda Cappuccio, Michele Pinelli, Marianna Alagia, Taraka Donti, Debra-Lynn Day-Salvatore, Pierangelo Veggiotti, Valentina De Giorgis, Simona Lunghi, Maria Stella Vari, Pasquale Striano, Nicola Brunetti-Pierri, Adam D Kennedy, Sarah H Elsea   +12 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Application of ketogenic diets for pediatric neurocritical care

Biomedical Journal, 2020
In this review, we summarize the general mechanisms of the ketogenic diet, and the application of a ketogenic diet in pediatric intensive care units for the neurological disorders of children and young infants.
Kuang-Lin Lin, Jann-Jim Lin, Huei-Shyong Wang   +2 more
doaj   +1 more source

Favorable response to ketogenic diet therapy in a patient with DYNC1H1-related epilepsy

Epilepsy & Behavior Reports
Dynein Cytoplasmic 1 Heavy chain 1 (DYNC1H1)-related disorders are a spectrum of conditions including neurodevelopmental disorders, congenital brain malformations, and neuromuscular diseases.
Chalongchai Phitsanuwong, Stephanie Schimpf, Sho T. Yano   +2 more
doaj   +1 more source

Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function

Angewandte Chemie, EarlyView.
Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou, Ling Zhang, Zhuoyi L. Niu, Xin Wang, Alejandro Storper, Ryan Hunt, Yingming Zhao, Nima Sharifi, Zhipeng A. Wang   +8 more
wiley   +2 more sources

ADCY3: the pivotal gene in classical ketogenic diet for the treatment of epilepsy

Frontiers in Cellular Neuroscience
ObjectiveEpilepsy is a common neurological disorder characterized by recurrent epilepsy episodes. As a non-pharmacological treatment, the ketogenic diet has been widely applied in treating epilepsy.
Mingxing Lin, Jiayin Gong, Luyan Wu, Xin Lin, Yuying Zhang, Wanhui Lin, Huapin Huang, Huapin Huang, Huapin Huang, Chaofeng Zhu   +9 more
doaj   +1 more source

Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2021
Background Brain energy metabolism is impaired in Alzheimer’s disease (AD), which may be mitigated by a ketogenic diet. We conducted a randomized crossover trial to determine whether a 12-week modified ketogenic diet improved cognition, daily function ...
Matthew C. L. Phillips, Laura M. Deprez, Grace M. N. Mortimer, Deborah K. J. Murtagh, Stacey McCoy, Ruth Mylchreest, Linda J. Gilbertson, Karen M. Clark, Patricia V. Simpson, Eileen J. McManus, Jee-Eun Oh, Satish Yadavaraj, Vanessa M. King, Avinesh Pillai, Beatriz Romero-Ferrando, Martijn Brinkhuis, Bronwyn M. Copeland, Shah Samad, Shenyang Liao, Jan A. C. Schepel   +19 more
doaj   +1 more source

The impact of the ketogenic diet on the health of patients with Alzheimer’s disease

Journal of Education, Health and Sport
INTRODUCTION: Diet is an integral element of every individual's health. Its impact on the functioning of the human body has fascinated scientists for years.
Julia Samborska, Paweł Więckowiak, Karina Stelmaszak, Katarzyna Stencel, Aleksandra Ogiegło-Kowalczyk, Monika Wojtasik, Michał Głodzik, Marek Miśkiewicz, Katarzyna Żak, Martyna Łęcka   +9 more
doaj   +1 more source

The effects of moderate-intensity continuous training and high-intensity interval training during a ketogenic diet on serum levels of irisin, PGC-1α and UCP1 in overweight and obese women [PDF]

فیزیولوژی ورزش و فعالیت بدنی
Background and Purpose: Nowadays, obesity has become a global challenge, and the use of strategies based on diet and exercise is recommended by experts and researchers for weight management.
Behnam Behravan, Kazem Khodaei, Mohammadreza Zolfaghardidani   +2 more
doaj   +1 more source

The ketogenic diet all grown up—Ketogenic diet therapies for adults

Epilepsy Research, 2020
The use of ketogenic diet therapies (KDT) in adults has expanded in the last two decades and has been accompanied by a surge of new retrospective as well as prospective studies evaluating its efficacy in adults with epilepsy. In this review article, we will highlight the recent clinical trials and advances in the use of the ketogenic diet therapy (KDT)
Khalil S, Husari, Mackenzie C, Cervenka
openaire   +3 more sources