Results 31 to 40 of about 1,080 (156)

In Vitro ADME, Preclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of RBx14255, a Novel Ketolide with Pharmacodynamics Against Multidrug-Resistant Bacterial Pathogens

Journal of Pharmacy & Pharmaceutical Sciences, 2020
Purpose: The preclinical pharmacokinetic and pharmacodynamic properties of a potent fluoroketolide RBx14255 against Streptococcus pneumoniae and Haemophilus influenzae was compared with telithromycin and human clinical dose was predicted for preclinical ...
Trdib Chaira, Tarani Barman, VETHAKKANI SAMUEL RAJ   +2 more
doaj   +1 more source

Antimicrobial prescriptions and adherence to prudent use guidelines for selected canine diseases in Switzerland in 2016

Veterinary Record Open, Volume 7, Issue 1, 2020., 2020
Background Antimicrobial resistance is an increasing problem in human and veterinary medicine and is closely linked to the use of antimicrobials. The objective of this study was to describe antimicrobial prescriptions for selected canine diseases in Switzerland during 2016. Methods Dogs presented to two university hospitals and 14 private practices for
Bérénice Lutz, Claudia Lehner, Kira Schmitt, Barbara Willi, Gertraud Schüpbach, Meike Mevissen, Ruth Peter, Cedric Müntener, Hanspeter Naegeli, Simone Schuller   +9 more
wiley   +1 more source

Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes

Annals of Clinical Microbiology and Antimicrobials, 2004
Background In streptococci, three macrolide resistance determinants (erm(B), erm(TR) and mef(A)) have been found. In addition, certain mutations at the ribosomal 23S RNA can cause resistance to macrolides. Mutation at the position 2058 of the 23S rRNA of
Huovinen Pentti, Vaara Martti, Jalava Jari   +2 more
doaj   +1 more source

New therapeutic approaches for treatment of tularaemia: a review

Frontiers in Cellular and Infection Microbiology, 2014
Antibiotic treatment of tularaemia is based on a few drugs, including the fluoroquinolones, the tetracyclines and the aminoglycosides. Because no effective and safe vaccine is currently available, tularaemia prophylaxis following proven exposure to F ...
Sandrine eBOISSET, Sandrine eBOISSET, Yvan eCASPAR, Yvan eCASPAR, Vivien eSUTERA, Vivien eSUTERA, Max eMAURIN, Max eMAURIN   +7 more
doaj   +1 more source

Medicinal and Crop Protection Chemistry: Breaking Barriers, Building Synergies

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A unified view of medicinal and crop protection chemistry reveals shared scientific progress, common challenges, and new opportunities for cross‐disciplinary collaboration. Bridging expertise across both fields could accelerate innovation and actively encourage more sustainable solutions.
Giulia Cazzaniga, Giusy L. Fratello, Alexander T. Apostle, Roberto Orru, David M. Barber, Silvia Gazzola   +5 more
wiley   +1 more source

Staphylococcus aureus with an erm-mediated constitutive macrolide-lincosamide-streptogramin B resistance phenotype has reduced susceptibility to the new ketolide, solithromycin

BMC Infectious Diseases, 2019
Background Solithromycin, the fourth generation of ketolides, has been demonstrated potent antibacterial effect against commonly-isolated gram-positive strains. However, Staphylococcus aureus (S.
Weiming Yao, Guangjian Xu, Duoyun Li, Bing Bai, Hongyan Wang, Hang Cheng, Jinxin Zheng, Xiang Sun, Zhiwei Lin, Qiwen Deng, Zhijian Yu   +10 more
doaj   +1 more source

Analysis of Virulence Genes and Antibiotic‐Resistant Profiles of Campylobacter in Huzhou, China

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background Campylobacter is the leading bacterial cause of diarrheal illnesses worldwide. Campylobacter jejuni and Campylobacter coli are the main pathogens of Campylobacter infections. Drug‐resistant Campylobacter has been classified as a serious antibiotic resistance threat. Methods From 2021 to 2022, 68 Campylobacter were isolated from fecal samples
Xiaofang Wu, Fenfen Dong, Zhonghao Lu, Lei Ji, Liping Chen, Satabdi Datta Choudhury   +5 more
wiley   +1 more source

Leclercia adecarboxylata Cholecystitis with Septic Shock in Immunocompetent Patient

Case Reports in Critical Care, Volume 2019, Issue 1, 2019., 2019
L. adecarboxylata is a Gram‐negative rod previously named Escherichia adecarboxylata, isolated as normal flora in the gut of animals including human stool. Most reported cases refer to immunocompromised patients with polymicrobial infections and water environments.
Nooraldin Merza, John Lung, Ahmed Taha, Ahmed Qasim, Jill Frost, Tarek Naguib, Mehmet Doganay   +6 more
wiley   +1 more source

Increased susceptibility to azithromycin of Pseudomonas aeruginosa biofilms using RPMI 1640 testing media

APMIS, Volume 132, Issue 12, Page 1086-1095, December 2024.
Azithromycin (AZM) is efficient for treatment of chronic Pseudomonas aeruginosa biofilm lung infections, despite of resistance in conventional susceptibility testing. It has been shown that planktonic P. aeruginosa are more susceptible to AZM when tested in RPMI 1640 medium. The aim of the study was to test the susceptibility to AZM of P.
Adrian Jimenez San San Mauro, Niels Høiby, Oana Ciofu   +2 more
wiley   +1 more source

Current Perspectives on Treatment of Gram‐Positive Infections in India: What Is the Way Forward?

Interdisciplinary Perspectives on Infectious Diseases, Volume 2019, Issue 1, 2019., 2019
The emerging antimicrobial resistance leading to gram‐positive infections (GPIs) is one of the major public health threats worldwide. GPIs caused by multidrug resistant bacteria can result in increased morbidity and mortality rates along with escalated treatment cost and hospitalisation stay.
Atul P. Kulkarni, Vasant C. Nagvekar, Balaji Veeraraghavan, Anup R. Warrier, Deepak TS, Jaishid Ahdal, Rishi Jain, Adalberto R. Santos   +7 more
wiley   +1 more source