Results 41 to 50 of about 1,080 (156)

Telitromicine. A new therapeutic option from macrolides to ketolides.

Medisur, 2004
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Pedro Miguel Milián Vázquez., Maira Quirós Enríquez., Arlette Linares Borges.   +2 more
doaj   +2 more sources

Ketolide Resistance Conferred by Short Peptides [PDF]

Journal of Biological Chemistry, 1998
Clones expressing pentapeptides conferring resistance to a ketolide antibiotic, HMR3004, were selected from a random pentapeptide mini-gene library. The pentapeptide MRFFV conferred the highest level of resistance and was encoded in three different mini-genes. Comparison of amino acid sequences of peptides conferring resistance to a ketolide with those
S, Tripathi, P S, Kloss, A S, Mankin
openaire   +2 more sources

Cross‐reactivity among and between macrolides, lincosamides, and streptogramins: Study on the French pharmacovigilance database

Fundamental &Clinical Pharmacology, Volume 38, Issue 5, Page 988-997, October 2024.
Abstract Background Hypersensitivity reactions (HSR) are reported for the macrolides, lincosamides, and streptogramins (MLS) antibiotic family. Data about cross‐reactivity among and between MLS remain scarce or controversial. Objectives The aim of this study was to provide an overview of hypersensitivity cross‐reactions among MLSs based on data ...
Quentin Le Baron, Delphine Bourneau‐Martin, Marina Babin, Aurore Gouraud, Marie Tauber, Audrey Fresse, Bénédicte Lebrun‐Vignes, Juliette Delaunay, Martine Morisset, Marie Briet   +9 more
wiley   +1 more source

ECDC, EFSA and EMA Joint Scientific Opinion on a list of outcome indicators as regards surveillance of antimicrobial resistance and antimicrobial consumption in humans and food‐producing animals

EFSA Journal, Volume 15, Issue 10, October 2017., 2017
Abstract ECDC, EFSA and EMA have jointly established a list of harmonised outcome indicators to assist EU Member States in assessing their progress in reducing the use of antimicrobials and antimicrobial resistance (AMR) in both humans and food‐producing animals. The proposed indicators have been selected on the basis of data collected by Member States
ECDC, EFSA Panel on Biological Hazards (BIOHAZ), EMA Committee for Medicinal Products for Veterinary Use (CVMP)   +2 more
wiley   +1 more source

The antibiotic resistance crisis and the development of new antibiotics

Microbial Biotechnology, Volume 17, Issue 7, July 2024.
The current Lilliput review analyses the question whether scientific or economic hurdles prevented the registration of new antibiotics. Scientifically, substantial progress has been achieved over recent years. The lack of profitability for costly novel antibiotic development necessitates push and pull efforts of the public sector to complement what the
Harald Brüssow
wiley   +1 more source

South African actinobacteria: A treasure trove of novel bioactive metabolites for drug discovery

South African Journal of Science
Although South Africa is known as one of the most biodiverse countries in the world, based on its unique plants and animals, microorganisms have received much less attention.
Kojo S. Acquah, David W. Gammon, Denzil R. Beukes   +2 more
doaj   +1 more source

In Vitro Activity of the Ketolide ABT-773 [PDF]

Antimicrobial Agents and Chemotherapy, 2001
ABSTRACT The in vitro activities of ABT-773, azithromycin, erythromycin, and clindamycin were compared by testing 1,223 clinical isolates selected to represent different species and phenotypes. ABT-773 was particularly potent against staphylococci (the MIC at which 90% of the strains tested were inhibited [MIC 90
A L, Barry, P C, Fuchs, S D, Brown
openaire   +2 more sources

What is the role of microbial biotechnology and genetic engineering in medicine?

MicrobiologyOpen, Volume 13, Issue 2, April 2024.
Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley   +1 more source

The energy landscape of the ribosome

Biopolymers, Volume 115, Issue 2, March 2024.
Abstract The ribosome is a prototypical assembly that can be used to establish general principles and techniques for the study of biological molecular machines. Motivated by the fact that the dynamics of every biomolecule is governed by an underlying energy landscape, there has been great interest to understand and quantify ribosome energetics.
Sandra Byju, Asem Hassan, Paul C. Whitford   +2 more
wiley   +1 more source

Intravenous azithromycin plus ceftriaxone followed by oral azithromycin for the treatment of inpatients with community-acquired pneumonia: an open-label, non-comparative multicenter trial

Brazilian Journal of Infectious Diseases
Community-Acquired Pneumonia (CAP) is a major public health problem. In Brazil it has been estimated that 2,000,000 people are affected by CAP every year. Of those, 780,000 are admitted to hospital, and 30,000 have death as the outcome.
Fernando G. Rubio, Clóvis A. Cunha, Fernando L.C. Lundgren, Maria P.J.S. Lima, Paulo J.Z. Teixeira, Julio C.A. Oliveira, Valdir Golin, Waldo L.L.D. Mattos, Herbert K. Mählmann, Edson D. Moreira, Jose R. Jardim, Rodney L.F. Silva, Patricia H.B. Silva   +12 more
doaj   +1 more source