Advanced Intelligent Systems, EarlyView.Poly(vinylidene fluoride) (PVDF)‐based ferroelectric materials exhibit high strains, energy densities and coupling efficiencies, appealing for diverse applications requiring smart material actuators. This work reviews electromechanical transduction in PVDF‐based polymers and their modifications, implementation in actuators, and functional devices ...
Giulio Gallucci, Andres Hunt
wiley +1 more source
Reply to “When Is a Ketogenic Diet Ketogenic? Comment on Satiating Effect of a Ketogenic Diet and Its Impact on Muscle Improvement and Oxidation State in Multiple Sclerosis Patients. Nutrients 2019, 11, 1156” [PDF]
, 2019 Benlloch, María +9 more
core +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt +9 more
wiley +1 more source
Building Molecules by a Self‐Replicator That Catalyzes Acyl Hydrazone Formation
Angewandte Chemie, EarlyView.A self‐replicator efficiently catalyzes the formation of acyl hydrazone bonds between a set of different substrates. In addition to previously reported (bond‐breaking) catalytic activity, this renders the self‐replicator highly promiscuous, which is a good starting point for Darwinian experiments en route to de‐novo life.
Kayleigh S. van Esterik +2 more
wiley +2 more sources
Investigation of the Neurotoxic Effects and Mechanisms of Michler's Ketone as Investigated by Network Toxicology and Transcriptomics. [PDF]
Biology (Basel)Hu J +7 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud +3 more
wiley +1 more source
Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice
Annals of Neurology, EarlyView.A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi +10 more
wiley +1 more source
An Expanded Toolbox for Versatile Chemical Editing of Adeno‐Associated Virus
Angewandte Chemie, EarlyView.We describe technology to introduce diverse non‐natural chemical functionalities site‐specifically into the capsid of adeno‐associated virus through genetic code expansion, and using them to engineer this leading vector for human gene therapy for enhanced tissue specificity and reduced immunogenicity Abstract Site‐specific incorporation of noncanonical
Quan Pham +6 more
wiley +1 more source
Divergent Total Synthesis of Denudatine Alkaloids Cochlearenine, Macrocentrine, Dictizine, 15-Veratroyl-17-Acetyl-19-Oxodictizine, and the Proposed Structure of Acochlearine. [PDF]
Angew Chem Int Ed EnglKawano S +5 more
europepmc +1 more source