Results 31 to 40 of about 350,483 (328)

Ketone Body, 3-hydroxybutyrate: Minor Metabolite - Major Medical Manifestations.

Journal of Clinical Endocrinology and Metabolism, 2020
Ketone bodies - 3-hydroxybutyrate (3-OHB), acetoacetate and acetone - are ancient, evolutionarily preserved, small fuel substrates, which uniquely can substitute and alternate with glucose under conditions of fuel and food deficiency. Once canonized as a
N. Møller
semanticscholar   +1 more source

A Review on the Catalytic Acetalization of Bio-renewable Glycerol to Fuel Additives

Frontiers in Chemistry, 2018
The last 20 years have seen an unprecedented breakthrough in the biodiesel industry worldwide leads to abundance of glycerol. Therefore, the economic utilization of glycerol to various value-added chemicals is vital for the sustainability of the ...
Amin Talebian-Kiakalaieh, Amin Talebian-Kiakalaieh, Nor Aishah Saidina Amin, Neda Najaafi, Sara Tarighi   +4 more
doaj   +1 more source

Synthesis of some novel hydrazono acyclic nucleoside analogues

Beilstein Journal of Organic Chemistry, 2010
The syntheses of novel hydrazono acyclic nucleosides similar to miconazole scaffolds are described. In this series of acyclic nucleosides, pyrimidine as well as purine and other azole derivatives replaced the imidazole function in miconazole and the ...
Mohammad N. Soltani Rad, Ali Khalafi-Nezhad, Somayeh Behrouz   +2 more
doaj   +1 more source

A Facile One-Pot Process for the Formation of Hindered Tertiary Amines

Molecules, 2012
A simple and convenient method was developed for the preparation of hindered tertiary amines via direct reductive amination of ketones with secondary aryl amines, using trichlorosilane as reducing agent and tetramethylethylenediamine (TMEDA) as organic ...
Jian Sun, Chao Wang, Yu Zhang, Zhouyu Wang, Dong Pei   +4 more
doaj   +1 more source

Divergent Hepatic Outcomes of Chronic Ketone Supplementation: Ketone Salts Preserve Liver Health While Ketone Esters and Precursors Drive Inflammation and Steatosis

Pharmaceuticals
Background/Objectives: Exogenous ketone supplements elevate circulating ketones without carbohydrate restriction, but their long-term hepatic safety remains unclear.
Csilla Ari, Dominic P. D’Agostino
doaj   +1 more source

Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure

Circulation: Heart Failure, 2020
Supplemental Digital Content is available in the text. Background: Accumulating evidence suggests that the failing heart reprograms fuel metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone delivery ameliorates ...
Salva R. Yurista, T. Matsuura, Herman H. W. Silljé, K. Nijholt, K. McDaid, Swapnil V. Shewale, T. Leone, John C. Newman, E. Verdin, D. V. van Veldhuisen, R. D. de Boer, D. Kelly, B. Westenbrink   +12 more
semanticscholar   +1 more source

Cardiac ketone body metabolism.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2020
The ketone bodies, d-β-hydroxybutyrate and acetoacetate, are soluble 4-carbon compounds derived principally from fatty acids, that can be metabolised by many oxidative tissues, including heart, in carbohydrate-depleted conditions as glucose-sparing ...
A. Kadir, K. Clarke, R. Evans
semanticscholar   +1 more source

Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease

Frontiers in Psychiatry, 2023
Ketogenic diets have a century-long history as a therapeutic tool to treat intractable epilepsy. Recently, a renewed interest in neuroketotherapeutics has arisen, with ketogenic diets being explored for the treatment of neurodegenerative diseases such as
Annette Bosworth, Vyvyane Loh, Blackjack N. Stranahan, Christopher M. Palmer   +3 more
doaj   +1 more source

Electroreductive Olefin-Ketone Coupling.

Journal of the American Chemical Society, 2020
A user-friendly approach is presented to sidestep the venerable Grignard addition to unactivated ketones to access tertiary alcohols by reversing the polarity of the disconnection. In this work a ketone instead acts as a nucleophile when adding to simple
Pengfei Hu, B. Peters, Christian A. Malapit, Julien C. Vantourout, Pan Wang, Jinjun Li, Lucas Mele, Pierre-Georges Echeverria, S. Minteer, P. Baran   +9 more
semanticscholar   +1 more source

Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects

Frontiers in Nutrition
IntroductionThe brain uses ketones, mainly 3-hydroxybutyrate (3-HB), as an alternative energy source. Therefore, oral intake of 3-HB may help maintain brain health.
Kentaro Nishioka, Kentaro Nishioka, Kentaro Nishioka, Takahiro Ishimoto, Mariko Sato, Ruki Yasuda, Yumi Nakamura, Hiroshi Watanabe, Toshihide Suzuki, Yudai Araragi, Yukio Kato, Ken-ichi Yoshida, Norihito Murayama   +12 more
doaj   +1 more source