Results 51 to 60 of about 331,332 (337)

In pursuit of β-amino α-nitro β-trifluoromethyl ketones: nitro-Mannich vs Mannich-type reactions [PDF]

, 2017
The reactivity of alfa-nitro ketones with trifluoromethyl aldimines is studied for the first time. While under nitro-Mannich conditions only the facial stereoselectivity can be controlled, organocatalysed Mannich-type reactions allowed a complete control
Ballini, Ballini, Ballini, Ballini, Bhadury, Carroccia, Carroccia, Chen, Claridge, Córdova, Dighe, Dinér, Donslund, Fioravanti, Fioravanti, Fioravanti, Fioravanti, Fioravanti, Gao, Ghosh, Hatano, Hurd, Ibrahem, Ilies, Kano, Kano, Kelly, Kobayashi, Kokotos, Levy, Merino, Mitsumori, Moteki, Nguyen, Nie, Noble, Parise, Parise, Pelagalli, Stach, Walaszek, Yang, Yin, Zhang, Zhang, Zheng   +45 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Ultraviolet-induced Surface Grafting of Octafluoropentyl Methacrylate on Polyether Ether Ketone for Inducing Antibiofilm Properties [PDF]

, 2017
Since octafluoropentyl methacrylate is an antifouling polymer, surface modification of polyether ether ketone with octafluoropentyl methacrylate is a practical approach to obtaining anti-biofilm biocompatible devices.
Amdjadi, Parisa, Dashtimoghadam, Erfan, Fahimipour, Farahnaz, Ghasemi, Amir, Najafi, Farhood, Nojehdehian, Hanieh, Seifi, Massoud, Tayebi, Lobat   +7 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Monitoring of Pediatric Type 1 Diabetes

Frontiers in Endocrinology, 2020
Regular self-monitoring of blood glucose levels, and ketones when indicated, is an essential component of type 1 diabetes (T1D) management. Although fingerstick blood glucose monitoring has been the standard of care for decades, ongoing rapid ...
Brynn E. Marks, Joseph I. Wolfsdorf
doaj   +1 more source

Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats [PDF]

, 2006
Pregnant Sprague–Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6 h/day, during days 6–20 of gestation.
Bourges-Abella, Nathalie, Cadot, R., Gallissot, Frédéric, Lambert, A.M., Morel, G., Sabaté, Jean-Philippe, Saillenfait, Anne-Marie   +6 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Effects of alkyl size of AlR3 on its reaction with thiophene-2-carbonyl chloride

Main Group Metal Chemistry
Reactions of AlEt3, Al(n-Oct)3, and AlEt2(n-Oct) with thiophene-2-carbonyl chloride (TPCC) at Al/TPCC (molar ratio)
Zhong Wentao, Yang Pengjia, Fu Zhisheng, Wang Qi, Fan Zhiqiang   +4 more
doaj   +1 more source

1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides with Carbonyl Dipolarophiles Yielding Oxazolidine Derivatives

Molecules, 2016
We provide a comprehensive account of the 1,3-dipolar cycloaddition reactions of azomethine ylides with carbonyl dipolarophiles. Many different azomethine ylides have been studied, including stabilized and non-stabilized ylides.
Adam G. Meyer, John H. Ryan
doaj   +1 more source

Synthesis and process optimization of electrospun PEEK-sulfonated nanofibers by response surface methodology [PDF]

, 2015
In this study electrospun nanofibers of partially sulfonated polyether ether ketone have been produced as a preliminary step for a possible development of composite proton exchange membranes for fuel cells.
Boaretti, Carlo, Lorenzetti, Alessandra, Modesti, Michele, Roso, Martina   +3 more
core   +2 more sources