Promiscuous Substrate-Binding explains the Enzymatic stereo and Regiocontrolled Synthesis of Enantiopure Hydroxy Ketones and Diols [PDF]
, 2009 Financial support from the Spanish Ministerio de Ciencia e Innovación (MICINN, Project CTQ2007-61126) and the Spanish Ministerio de Asuntos Exteriores y de Cooperación (Programa de Cooperación Interuniversitaria, PCI Iberoamérica MAEC-AECID, Project A ...
Bennet +51 more
core +2 more sources
Steric vs. electronic effects in the Lactobacillus brevis ADH-catalyzed bioreduction of ketones [PDF]
, 2014 W. B. thanks the Ministerio de Educación, Cultura y Deporte for her predoctoral fellowship (FPU Program). I. L. thanks the Spanish Ministerio de Ciencia e Innovación (MICINN) for personal funding (Ramón y Cajal Program). Financial support of this work by
Borzecka, Wioleta Anna +5 more
core +1 more source
Native proteins in organic chemistry. Recent achievements in the use of non hydrolytic enzymes for the synthesis of pharmaceuticals [PDF]
, 2016 Financial support by the Spanish Ministerio de Economia y Competitividad (MINECO) through the CTQ-2013-44153-P project is grateful acknowledged. M.L.-I.
Gotor Fernández, Vicente +2 more
core +2 more sources
Fluorogenic kinetic assay for high-throughput discovery of stereoselective ketoreductases relevant to pharmaceutical synthesis [PDF]
, 2017 Enantiomerically pure 1-(6-methoxynaphth-2-yl) and 1-(6-(dimethylamino)naphth-2-yl) carbinols are fluorogenic substrates for aldo/keto reductase (KRED) enzymes, which allow the highly sensitive and reliable determination of activity and kinetic constants
Black, Gary +5 more
core +1 more source
Imidazolium-Based Ionic Liquids as Non-conventional Media for Alcohol Dehydrogenase-Catalysed Reactions [PDF]
, 2014 The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under Grant Agreement No. 238531 (BIOTRAINS Marie Curie Initial Training Network).
Gotor Fernández, Vicente +3 more
core +1 more source
Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function
Angewandte Chemie, EarlyView.Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou +8 more
wiley +2 more sources
Sn-Beta zeolites with borate salts catalyse the epimerization of carbohydrates via an intramolecular carbon shift [PDF]
, 2012 Carbohydrate epimerization is an essential technology for the widespread production of rare sugars. In contrast to other enzymes, most epimerases are only active on sugars substituted with phosphate or nucleotide groups, thus drastically restricting ...
A Corma +45 more
core +1 more source
Why Leave a Job Half Done? Recent Progress in Enzymatic Deracemizations [PDF]
, 2015 Financial support of this work by the Spanish MICINN (Projects CTQ2011-24237 and CTQ2013-44153) is gratefully ...
Díaz Rodríguez, Alba +2 more
core +2 more sources
Stereoselective enzymatic reduction of 1,4-diaryl-1,4-diones to the corresponding diols employing alcohol dehydrogenases [PDF]
, 2018 Due to the steric hindrance of the starting prochiral ketones, the preparation of chiral 1,4-diaryl-1,4-diols through the asymmetric hydrogen transfer reaction has been mainly restricted to the use of metal-based catalysts, oxazaborolidines, or ...
Gonzalo Calvo, Gonzalo de +3 more
core +4 more sources
Differential Hydrogen Bonding in Human CYP17 Dictates Hydroxylation versus Lyase Chemistry [PDF]
, 2013 Consequences of alternative H-bonding: Raman spectra of oxygenated intermediates of Nanodisc-incorporated human CYP17 in the presence of natural substrates (pregnenolone and progesterone) directly confirm that substrate structure effectively alters ...
Gregory, Michael +3 more
core +2 more sources