Results 31 to 40 of about 3,610 (123)

Two‐Step Synthesis of a Chiral Fluorinated Alcohol With Silica‐Supported Enzyme RrADH in Batch and Continuous Flow Mode

Chemistry – A European Journal, EarlyView.
A two‐step process was transferred from batch to flow mode for the synthesis of (R)‐2‐fluoro‐1‐phenylethanol as a benchmark, consisting of a decarboxylative fluorination in aqueous media, followed by an enantioselective biocatalytic reduction of the prochiral intermediate with RrADH immobilized on silica supraparticles.
Egzon Cermjani, Greta Nölke, Stefano Di Fiore, Christoph Deckers, Doris Hanselmann, Bettina Herbig, Susanne Wintzheimer, Thomas H. Rehm   +7 more
wiley   +1 more source

Biotransformation of explosives by the old yellow enzyme family of flavoproteins [PDF]

, 2004
Several independent studies of bacterial degradation of nitrate ester explosives have demonstrated the involvement of flavin-dependent oxidoreductases related to the old yellow enzyme (OYE) of yeast. Some of these enzymes also transform the nitroaromatic
Bruce, N.C., Rathbone, D.A., Scrutton, N.S., Williams, R.E.   +3 more
core   +2 more sources

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Modulation of the glyoxalase system in the aging model Podospora anserina : effects on growth and lifespan [PDF]

, 2010
The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathionelyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic alpha-oxoaldehydes like methylglyoxal (
Gispert, Suzana, Mack, Sandra J., Osiewacz, Heinz D., Ricciardi, Filomena, Scheckhuber, Christian Q., Strobel, Ingmar   +5 more
core   +2 more sources

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

To what extent do structural changes in catalytic metal sites affect enzyme function? [PDF]

, 2017
About half of known enzymatic reactions involve metals. Enzymes belonging to the same superfamily often evolve to catalyze different reactions on the same structural scaffold.
Andreini, Claudia, Furnham, Nicholas, Rosato, Antonio, Thornton, Janet M, Valasatava, Yana   +4 more
core   +2 more sources

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Substrate specificity and regioselectivity of fungal AA9 lytic polysaccharide monooxygenases secreted by Podospora anserina [PDF]

, 2015
International audienceBackground: The understanding of enzymatic polysaccharide degradation has progressed intensely in the past few years with the identification of a new class of fungal-secreted enzymes, the lytic polysaccharide monooxygenases (LPMOs ...
Bennati-Granier, Chloé, Berrin, Jean-Guy, Champion, Charlotte, Fanuel, Mathieu, Garajova, Sona, Gimbert, Isabelle, Grisel, Sacha, Haon, Mireille, Record, Eric, Rogniaux, Hélène, Ropartz, David, Zhou, Simeng   +11 more
core   +4 more sources

Linking Nutritional, Sensory, and Functional Quality in Plant‐Based Proteins Through Structural Modification and Computational Insights

Sustainable Food Proteins, Volume 4, Issue 1, March 2026.
The lacking essential amino acids, low digestibility, bioavailability, bitterness, and presence of anti‐nutritional factors that limit the consumption of plant proteins and their use in food formulations are discussed comprehensively. The findings of recent studies on novel technologies and computer‐based applications used to cope with these challenges
Humeyra Cavdar Dincturk, Rukiye Gundogan, Asli Can Karaca, Esra Capanoglu   +3 more
wiley   +1 more source