Results 41 to 50 of about 3,610 (123)

Deep Eutectic Solvents: The Organic Reaction Medium of the Century [PDF]

open access: yes, 2016
This microreview summarizes the use of deep eutectic solvents (DESs) and related melts in organic synthesis. Solvents of this type combine the great advantages of other proposed environmentally benign alternative solvents, such as low toxicity, high ...
Abbott   +192 more
core   +2 more sources

Taxonomic and functional shifts in the microbiome of severely obese, prediabetic patients: Ketogenic diet versus energy‐matched standard diet

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1826-1835, March 2026.
Abstract Aims Obesity and type 2 diabetes mellitus (T2DM) are among the leading global health challenges of the 21st century. While caloric restriction remains the cornerstone of weight loss interventions, ketogenic diets (KD), characterised by low carbohydrate and high fat intake, have been shown to improve metabolic health partly by modulating the ...
June Stone   +5 more
wiley   +1 more source

Mild Short‐Term Caloric Restriction Induces Coordinated Changes That Promote Lipid Deposition While Maintaining Thermogenesis Capacity in Interscapular Brown Adipose Tissue of Male Rats

open access: yesThe FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Rats under mild caloric restriction (85% vs. ad libitum) for 2 weeks show metabolic and structural adaptations in iBAT. Caloric restriction increases glycolysis and triglyceride deposition in the tissue, leading to larger lipid droplets. It also reduces mitochondrial iBAT content, while maintaining iBAT thermogenic potential thanks to an increased ...
Giuliana Panico   +11 more
wiley   +1 more source

Enzyme-modified particles for selective biocatalytic hydrogenation by hydrogen-driven NADH recycling [PDF]

open access: yes, 2015
We describe a new approach to selective H-2-driven hydrogenation that exploits a sequence of enzymes immobilised on carbon particles. We used a catalyst system that comprised alcohol dehydrogenase, hydrogenase and an NAD(+) reductase on carbon black to ...
Lauterbach, Lars   +3 more
core   +2 more sources

A Comprehensive Review of Acne Treatments: Unpacking the Chemical Structures and Effective Bioactive Compounds

open access: yesHealth Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Acne vulgaris is a frequent skin disorder, affecting a large part of the population worldwide, and strongly influencing not only the physical but also the mental aspects of health. The choice of therapy for acne vulgaris is a very difficult one because the multifactorial causality of the disease and interindividual ...
Mobina Tajdari   +5 more
wiley   +1 more source

MiR‐18a‐5p Attenuates Oxidative Stress and Inhibits Lipid Accumulation in Alcoholic Fatty Liver by Activating the CYP1A1‐PPAR Axis

open access: yesImmunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Lipid deposition in alcoholic fatty liver disease (AFL) represents an early stage in alcoholic liver disease progression and may contribute to carcinogenesis. MicroRNAs (miRNAs) play critical regulatory roles in liver biological processes. Methods In this study, we explored the miR‐18a‐5p/CYP1A1/PPAR axis in AFL using bioinformatics
XueMei Zhang   +10 more
wiley   +1 more source

Screening of Microorganisms Producing Cold-Active Oxidoreductases to Be Applied in Enantioselective Alcohol Oxidation. An Antarctic Survey [PDF]

open access: yes, 2011
Several microorganisms were isolated from soil/sediment samples of Antarctic Peninsula. The enrichment technique using (RS)-1-(phenyl)ethanol as a carbon source allowed us to isolate 232 psychrophile/psychrotroph microorganisms.
Allan   +43 more
core   +4 more sources

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

open access: yesInternational Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao   +6 more
wiley   +1 more source

Glucose concentration in capillary blood of dairy cows obtained by a minimally invasive lancet technique and determined with three different hand-held devices [PDF]

open access: yes, 2016
Background Dairy cows have a massive demand for glucose at the onset of lactation. A poor adaption to this period leads to an excessive negative energy balance with an increased risk for ketosis and impaired animal health and production.
Borchardt, S.   +7 more
core   +2 more sources

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang   +10 more
wiley   +1 more source

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