Results 91 to 100 of about 6,647,574 (329)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Teaching teachers in effectual entrepreneurship [PDF]

, 2013
Entrepreneurship and entrepreneurship education is seen by all kind of people to be important for economic growth. Teaching entrepreneurship needs another approach. Active learning and the constructivism is mostly seen as essential.
Hakkert, A., Hammer, M., Koopman, R.G.M.
core   +2 more sources

European reference framework of key competences for lifelong learning: an updated 2018 version

Ukrainian Educational Journal, 2019
The author noted the importance for the European education of the European reference framework of key competencies for lifelong learning (2006) and its impact on the development of education in Ukraine. The synchronization of the vision of the competency
O. Lokshyna
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Stakeholder engagement as a facilitator of organizational learning [PDF]

, 2008
This paper examines the relationship between stakeholder engagement and competence building. Following the dual perspective of the firm, which indicated that managers deal with both transactions and competences concurrently, we argue that stakeholder ...
Eweje, Gabriel, Wu, Minyu
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The Framework Catalogue of Digital Competences [PDF]

, 2015
The Framework Catalogue of Digital Competences Justyna Jasiewicz, Mirosław Filiciak, Anna Mierzecka, Kamil Śliwowski, Andrzej Klimczuk, Małgorzata Kisilowska, Alek Tarkowski & Jacek Zadrożny Centrum Cyfrowe Projekt: Polska ...
Filiciak, Mirosław, Jasiewicz, Justyna, Kisilowska, Małgorzata, Klimczuk, Andrzej, Mierzecka, Anna, Tarkowski, Alek, Zadrożny, Jacek, Śliwowski, Kamil   +7 more
core   +6 more sources

Key competences of logistics and SCM professionals – the lifelong learning perspective

, 2018
Purpose The purpose of this study is to identify specific qualifications and competences required within the field of logistics and supply chain management from the perspective of lifelong learning and hierarchical level.
H. Kotzab, Christoph Teller, M. Bourlakis, Sebastian Wünsche   +3 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Developing the methodological instructions of art education supporting key competences and subject-specific competence

Eesti Haridusteaduste Ajakiri
Eesti õpetajad on hästi ette valmistatud aine õpetamiseks, kuid ebakindlamalt tuntakse end kunsti osaoskuste ja üldpädevuste seostamisel. Eesti uuendatud riiklik õppekava näeb kunsti ainekavas ette ainepädevuse ja üldpädevuste ühendamist.
Helen Arov, Anneli Porri, Edna Vahter, Erika Löfström   +3 more
doaj   +1 more source