Results 161 to 170 of about 11,653,432 (296)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Princess Theatre and office of Senator Shane Murphy, Brisbane Street, Launceston [picture] /

, 1995
Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an11892262 ...
Key, Mike, 1951-
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Boags Brewery Building, 47 William Street, Launceston [picture] /

, 1995
Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an11892262 ...
Key, Mike, 1951-
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Stabilization of compressed earth blocks using recycled thermoplastics: experimental study of key parameters. [PDF]

Sci Rep
Salem LH, Aly Y, Arab B, Haggag M, Khedr S.   +4 more
europepmc   +1 more source

Empire Hotel, Orr Street, Queenstown. Built in 1901 [picture].

, 1995
Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an11892265 ...
Key, Mike, 1951-
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Evaluating molecular docking for binding affinity predictions: a systematic analysis of key parameters and the utility of AlphaFold2 structures for the Schrödinger dataset. [PDF]

J Comput Aided Mol Des
Tornesakis K, Essex JW, Cox PA, König G.   +3 more
europepmc   +1 more source

Turriff Lodge Oast House, New Norfolk [picture].

, 1995
Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an11892270 ...
Key, Mike, 1951-
core