Results 121 to 130 of about 334,680 (245)

Exergy Efficiency Is a Key Performance Indicator to Rank Advanced Active Energy Technologies at the District Level. [PDF]

Entropy (Basel)
Favrat D.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Lessons from implementation of a nephrology key performance indicator programme. [PDF]

Intern Med J
Steinberg AG, Mount PF, Branagan M, Roberts MA, Toussaint ND.   +4 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Development of a key performance indicator set for perioperative red blood cell transfusion. [PDF]

BJA Open
Shah A, Evans HG, Palmer AJR, MacDonald AM, Belete M, von Neree L, Murphy MMF, Stanworth SJ, Foy R, NIHR Blood and Transplant Research Unit in Data Driven Transfusion Practice.   +9 more
europepmc   +1 more source

Key performance indicators for the indoor environment

, 2011
The overall quality of the indoor environment in which people live, work and spend their time and artefacts remain, is the result from a complex integration of a large number of physical attributes. These attributes result from an integration of a large number of building components.
Loomans, M.G.L.C., Huovila, Aapo, Lefebvre, Pierre-Henri, Porkka, Janne, Huovila, Pekka, Desmyter, Jan, Vaturi, Asher   +6 more
openaire   +3 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

What Clinical Pharmacy Key Performance Indicator Processes of Care Were Patients Receiving across Canada in 2018? A National Patient Registry and Pooled Analysis. [PDF]

Can J Hosp Pharm
Carroccia A, Fernandes OA, Toombs K, Gorman SK, Spina SP, Semchuk WM, Meade A, Lowe D, Bayoud T, Shalansky S, Facca NM, Seto W, Bussières JF, Wong GG, Lui P, Slavik RS, Doucette D, Latariya G, Chant C.   +18 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source