Results 131 to 140 of about 1,421,153 (287)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Research on the performance evaluation model of national key special projects of blood center

open access: yesZhongguo shuxue zazhi
[Objective] To establish performance evaluation indicators and provide a scientific and reliable method for the performance evaluation for national key special projects of blood center.
HOU Wei
doaj   +1 more source

Shopping centres maintenance management performance: A case study [PDF]

open access: yesFME Transactions, 2015
A Shopping Centre (SC) is a ''shop open to the public', installed in a building, which include parking, several shops, technical, management, and shopping arcade.
Moreira Joaquim   +2 more
doaj  

TEACHER PERFORMANCE OF WOOD CONSTRUCTION DEPARTMENTIN STUDY PROCESS IN THE IMPLEMENTATION OF PIONEERING OF SCHOOL WITH INTERNATIONAL STANDARD (RSBI) AT SMK N 2 PENGASIH [PDF]

open access: yes, 2011
Today, pioneering of school with international standard (RSBI) becomes a program considered by the government. Based on SK DPSMK 4294/C5.3/Kep/KU/2009, SMKN 2 Pengasih has been trusted by the government to implement this program.
Singgih Kurniadi, Isnanto
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

ProcessM: Intelligent Process Mining software

open access: yesSoftwareX
Contemporary software guides and executes various business processes, such as production, delivery of goods, sales, and official procedures. However, due to software flexibility, unforeseen circumstances, and exceptional conditions, processes may not ...
Tomasz P. Pawlak, Jędrzej Potoniec
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

KPI-Based Evaluation Framework for Cyber Resilience of Ships

open access: yesIEEE Access
Advancements in information and communication technologies have improved operational efficiency in the maritime industry through the integration of operational technology and information technology systems.
Areum Ko, Ju Hyeon Lee, Jung Taek Seo
doaj   +1 more source

Pooling versus Model Selection for Nowcasting with Many Predictors: An Application to German GDP [PDF]

open access: yes
This paper discusses pooling versus model selection for now- and forecasting in the presence of model uncertainty with large, unbalanced datasets. Empirically, unbalanced data is pervasive in economics and typically due to di¤erent sampling frequencies ...
Christian Schumacher   +2 more
core  

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