Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion
An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang +10 more
wiley +1 more source
From words to action? Linking ESG reports to environmental performance. [PDF]
Savin I, Carel ML, Schlindwein E.
europepmc +1 more source
Modulation of Epigenetic Control by Advanced Molecular Tweezers
Tailored dimeric molecular tweezers recognize the DNA‐binding part of Histone H4 and interrupt the essential histone‐DNA interaction. ABSTRACT This work addresses the question if supramolecular systems can be tailored to interfere with posttranslational modifications (PTM) and epigenetics.
My‐Hue‐Le +9 more
wiley +1 more source
Implementing a manual dashboard for blood center management in under-resourced settings. [PDF]
Thakur SK +7 more
europepmc +1 more source
Energy Flexibilization and Demand Response for a Novel Decentralized Power‐to‐Methanol Process
This study presents the results of an optimization framework for the scheduling of a Power‐to‐methanol process coupled with an electrolyser, renewable energy sources and a battery. The optimal dynamic operating schedule is computed with different configurations and boundary conditions, showing the advantages of flexible operation.
Max Kollmer +5 more
wiley +1 more source
Climate dependent feasibility of closing water and nutrient cycles in industrial aqua-agriculture. [PDF]
de Korte M +6 more
europepmc +1 more source
Abstract This work presents a simplified extended‐batch adsorber analogue model (e‐BAAM) to quantify key performance metrics such as purity, recovery, and energy trends for various pressure swing adsorption (PSA) process cycles for CO2$$ {\mathrm{CO}}_2 $$ capture.
Gwyneth Liske, Arvind Rajendran
wiley +1 more source
AI based tool for monitoring intensity and fatigue in elite women handball. [PDF]
Felice F.
europepmc +1 more source
ABSTRACT This study investigates the adoption of Diversity and Inclusion (D&I) standards among Italian small and medium‐sized enterprises (SMEs), focusing on the international guideline ISO 30415:2021 and the national certification UNI/PdR 125:2022. Using survey data from 866 SMEs across six manufacturing and service industries and applying descriptive
Laura Bravi +2 more
wiley +1 more source
A Centralized AI Lakehouse Framework for Brain Tumor MRI Classification and Segmentation, University KPI Forecasting, and Water Potability Prediction. [PDF]
Shrestha R +5 more
europepmc +1 more source

