Results 61 to 70 of about 338,284 (271)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Dynamic failure of roadways under dynamic disturbances – a physical modeling study

Results in Engineering
Ensuring the stability of deep coal mine roadways under dynamic disturbances remains a critical challenge in underground mining engineering. While prior research has demonstrated the benefits of support systems, the failure mechanisms of anchored ...
Lei Yang, Fuqiang Gao, Zhiguo Lu, Xiaoqing Wang, Yukai Fu   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Key technology of overlapping tunnel construction with earth pressure balance shield method in rheological strata

Journal of Physics: Conference Series, 2021
Abstract Based on the existing bridge structure of Foshan Metro Line 2, this paper summarizes the engineering geological conditions of the overlapping tunnels, uses three-dimensional finite element analysis, establishes an engineering geological model, and analyzes the parameters of the upper tunnel in the disturbed surrounding rock ...
Qingru Yu, Shihong Zhai, Wen Liu, Tianrui Liu, Hu Song   +4 more
openaire   +1 more source

Mechanisms of Mining Seismicity under Large Scale Exploitation with Multikey Strata

Shock and Vibration, 2015
The dynamic disasters are aggravating with the increase of exploitation scale and intensity in Chinese coal mines, to further understand this problem, we studied the mechanisms of mining tremors induced by key strata movement and instability under large ...
Hu He, Linming Dou, Anye Cao, Jun Fan
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Study on the Bearing Structure of Key Strata and the Linkage Evolution Mechanism of Surface Subsidence in Shallow Coal Seam Mining

Applied Sciences
Shallow coal seam mining results in the formation of various bearing structures in key strata, leading to varying degrees of surface subsidence and severe disruption to the surface ecological environment.
Yifeng He, Jie Zhang, Tao Yang, Jianjun Wu, Shoushi Gao, Jianping Sun   +5 more
doaj   +1 more source

A Study on the Mechanism of Dynamic Pressure during the Combinatorial Key Strata Rock Column Instability in Shallow Multi-coal Seams

Advances in Civil Engineering, 2021
In order to study the pressure changes and support failure in mining face under concentrated coal pillar in shallow coal seam, the concentrated coal pillar in 30105 working face of Nan Liang Coal Mine was selected as the research object.
Jie Zhang, Bin Wang, Wenyong Bai, Sen Yang   +3 more
doaj   +1 more source

Pilot investigation of remote sensing for intertidal oyster mapping in coastal South Carolina: a methods comparison [PDF]

, 2003
South Carolina’s oyster reefs are a major component of the coastal landscape. Eastern oysters Crassostrea virginica are an important economic resource to the state and serve many essential functions in the environment, including water filtration, creek ...

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