Results 111 to 120 of about 181,059 (277)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Innovation and development from bedding separation grouting to overburden isolated grouting
Meitan xuebaoThe mining of coal under buildings has always been a major technical challenge for coal mines. To address this issue in China, the bedding separation grouting subsidence reduction experiments were carried out from the 1980s in about 10 coal mines ...
Jialin XU +3 more
doaj +1 more source
Meikuang Anquan, 2021 The dynamic disaster induced by mining disturbance is a major problem that affects coal mine safety production. The root cause lies in the large amount of elastic energy in the original rock. Combined with the occurrence status of coal seam geological structure in Huainan Mining Area and the characteristics of a historical dynamic disaster accident ...
openaire +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
Mechanism of Stratum Instability and Dynamic Deformation under Discontinuous Boundary Conditions
Applied SciencesA fault disrupts the continuity of the rock strata in a mining area. To study the law governing the fracture of overlying strata in mining areas under discontinuous boundary conditions, the overlying strata were redefined and grouped based on the ...
Hanxiao Guo +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Frontiers in Earth ScienceThe evolution of overlying strata structures significantly influences the manifestation of ground pressure behavior in working faces. The mechanism through which tectonic stress influences the evolution of overlying rock structures remains unclear.
Zhijie Zhu +4 more
doaj +1 more source
A note on the stratification by automorphisms of smooth plane curves of genus 6
, 2017 In this note, we give a so-called representative classification for the strata by automorphism group of smooth $\bar{k}$-plane curves of genus $6$, where $\bar{k}$ is a fixed separable closure of a field $k$ of characteristic $p = 0$ or $p > 13$.
Badr, Eslam, García, Elisa Lorenzo
core
Aging and Cancer, EarlyView.This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha +4 more
wiley +1 more source