Results 31 to 40 of about 626 (154)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 916-927, April 2026.
Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maud Maillard, Matthias Schwab, Michelle Whirl‐Carrillo, Ann M. Moyer, Guilherme Suarez‐Kurtz, Ching‐Hon Pui, C. Michael Stein, Teri E. Klein, Claire Spahn, Sooyeon Kwon, Juanda Leo Hartono, Nanne K. de Boer, Tariq Ahmad, Federico Guillermo Antillon‐Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E. J. Yeoh, Kjeld Schmiegelow, Jun J. Yang   +18 more
wiley   +1 more source

Hesperidin Attenuates H₂O₂‐Induced Neurotoxicity via Modulation of Inflammatory Pathways and MMP Activity in Differentiated SH‐SY5Y Cells: In Vitro and In Silico Models

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 3, March 2026.
Hesperidin protects differentiated SH‐SY5Y cells from H₂O₂‐induced neurotoxicity by reducing oxidative stress and suppressing pro‐inflammatory cytokines. It further inhibits NF‐κB/COX‐2 signaling and downregulates MMP‐2/MMP‐9 activity. In vitro findings are supported by in silico analyses showing strong binding to inflammatory targets. ABSTRACT Chronic
Hamiyet Eciroglu‐Sarban, Fatma Yildiz, Fatma Gonca Kocanci, Pinar Altin‐Celik, Muazzez Derya‐Andeden   +4 more
wiley   +1 more source

THE ASSESSMENT OF ARIDITY IN LESKOVAC BASIN, SERBIA (1981–2010)

Zbornik Radova: Geografski institut "Jovan Cvijić", 2018
In the paper, the aridity is defined on the basis of four climate indices: De Martonne's index of aridity, Lang’s Rain Factor and Gračanin’s Rain factor for the vegetation period and hydrothermal coefficient of Seljaninov.
Nikola Milentijević, Jovan Dragojlović, Dušan Ristić, Marija Cimbaljević, Dunja Demirović, Aleksandar Valjarević   +5 more
doaj   +1 more source

A Feast of Things with the KFG [PDF]

Commonplace, 2021
Dawit Tegbaru, Quincy Childs, Catherine Ahearn, Travis Rich, Allison Vanouse, Sarah Kearns, Ben Howe, Ian Reynolds, Eric McDaniel, Gabriel Stein, Samuel J. Klein, Zach Verdin, Pine Wu   +12 more
openaire   +1 more source

Comparing Movement Patterns and Physical Function Between Chronic Low Back Pain Patients With Nociplastic and Nociceptive Pain Categories

JOR SPINE, Volume 9, Issue 1, March 2026.
Are differences in perceived disability between nociceptive and nociplastic cLBP patients reflected in actual movement patterns or in patients' perceived functional ability? Despite worse patient‐reported disability, primarily nociplastic patients did not exhibit worse biomechanical function when compared to primarily nociceptive patients.
Erin Archibeck, Nicholas Harris, Patricia Zheng, Aaron Scheffler, Wolf Mehling, Conor O'Neill, Jeffrey Lotz, Grace O'Connell, Jeannie F. Bailey, REACH Investigators, Zehra Akkaya, Prakruthi Amarkumar, Jeannie Bailey, Julia Barylak, Sigurd Berven, Andrew Bishara, Dennis M. Black, Noah Bonnheim, Atul Butte, Joel Castellanos, Jennifer Cummings, Karina Del Rosario, Emilia Demarchis, Sibel Demir‐Deviren, Susan K. Ewing, Adam R. Ferguson, Aaron Fields, Scott M. Fishman, Sergio Garcia Guerra, Fatemeh Gholi Zadeh Kharrat, Xiaojie (Summer) Guo, Misung Han, Trisha Hue, J. Russell Huie, C. Anthony Hunt, Anastasia Keller, Karim Khattab, Roland Krug, Gregorji Kurillo, Feng Lin, Thomas Link, Jeffrey Lotz, John Lynch, Tong Lyu, Rob Matthew, Wolf Mehling, Esmeralda Mendoza, Praveen Mummaneni, Caroline Navy, Conor O’Neill, Jessica Ornowski, Thomas Peterson, Ananya Rupanagunta, Aaron Scheffler, Shalini Shah, Irina Strigo, Naoki Takegami, Abel Torres‐Espin, Salvatore Torrisi, Sachin Umrao, Rohit Vashisht, Joanna Veres, An (Joseph) Vu, Mark Steven Wallace, Lucy Ann Wu, Po‐Hung Wu, Fadel Zeidan, Patricia Zheng, Jiamin Zhou   +68 more
wiley   +1 more source

Vom Bibliotheksgesetz zum Kulturfördergesetz. Neue Wege der Kulturpolitik in Nordrhein-Westfalen? Eine Kurzbetrachtung.

o-bib. Das offene Bibliotheksjournal, 2014
Der Landtag Nordrhein-Westfalen hat im Sommer 2011 mit seiner Mehrheit der regierenden Koalition aus SPD und Bündnis90/Die Grünen den im Herbst 2010 von der Fraktion der CDU eingebrachten Entwurf eines Bibliotheksgesetzes zugunsten eines allgemeinen ...
Harald Pilzer
doaj   +1 more source

A Bioethical Assessment of the Environmental Impacts of War

Bioethics, EarlyView.
Funda Gülay Kadioglu
wiley   +1 more source

Genome‐wide association study identifies consistent genomic loci for yield and nutritional quality in Ethiopian sorghum landraces

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Identifying genomic regions linked to yield and quality is crucial for sorghum (Sorghum bicolor L.) improvement, but limited studies on its genome and diversity hinder breeding efforts. This study aimed to identify phenotypic variance and common quantitative trait nucleotides (QTNs) associated with genomic regions linked with grain yield and ...
Chalachew Endalamaw, Temesgen M. Menamo, Firezer G. Kebede, Zeleke Wondimu, Hailekiros Tadesse Tekle, Kwame Shamuyarira, Angeline Jacoby, Maryke Tine Labuschagne   +7 more
wiley   +1 more source

OTOMOBİL SEKTÖRÜNDE BİR KALİTE FONKSİYON GÖÇERİMİ UYGULAMASI

Selçuk Üniversitesi Sosyal Bilimler Meslek Yüksekokulu Dergisi, 2014
Müşteri isteklerinin önem kazandığı günümüz piyasa koşullarında, firmalar rekabet güçlerini artırmak için hızla değişen bu müşteri isteklerine en kısa sürede yanıt vermek zorundadırlar. Bu ortamda işletmeler hayatta kalabilmek için, artan müşteri ihtiyaç
Dilşad Güzel, Osman Demirdöğen, Salih Börteçine Avcı   +2 more
doaj  

Study on the bone mineral density of broiler suffering femoral joint degenerative lesions

Brazilian Journal of Poultry Science, 2008
An experiment was carried out with male and females broilers of two different commercial breeds to evaluate bone mineral density of the right femur head.
Almeida Paz ICL, AA Mendes, A Balog, LC Vulcano, AW Ballarin, ICL Almeida, SE Takahashi, CM Komiyama, MC Silva, KFG Cardoso   +9 more
doaj   +1 more source