Results 171 to 180 of about 833,353 (279)

Integrative Cross-platform Analysis of Kinase Inhibitor Effects on Statin-relevant Cardioprotective Pathways in Human Cardiomyocytes. [PDF]

Cancer Genomics Proteomics
Kuo TY, Cheng MC, Jhou HJ, Lee CH, Chen PH.   +4 more
europepmc   +1 more source

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

Development of an isavuconazole physiologically-based pharmacokinetic model for adult and pediatric populations. [PDF]

J Pharmacokinet Pharmacodyn
Choules MP, Desai A, Kovanda LL, Otsuka Y, Brüggemann RJ, Bonate PL.   +5 more
europepmc   +1 more source

Nonreciprocal Swarmalators With Reconfigurable and Controllable Formations for Robot Collectives

Advanced Robotics Research, EarlyView.
Nonreciprocal swarmalator interactions are enabled through control barrier functions to transform self‐organizing robot collectives into reconfigurable, constraint‐aware systems. Complex two‐ and three‐dimensional shapes, continuous morphing, obstacle‐aware navigation, collective splitting, and object transport emerge from modulating agent‐level ...
Kush Patel, Xinyue Xu, Wei Xiao, Steven Ceron   +3 more
wiley   +1 more source

Clobazam and Valproate, but Lamotrigine, a Sodium Channel Inhibitor, Reduce the Incidence of Hyperthermia-Induced Clonic Seizures in Dravet Syndrome Mice: Assessment of Anti-Seizure Effects in Mice Using a Stabilized Ambient Temperature System. [PDF]

Neuropsychopharmacol Rep
Sato F, Nakamura M, Oishi M, Matsuo Y, Amada N, Wadatsu T, Jinnai N, Kakumoto Y, Maeda K, Yamasaki Y, Futamura T.   +10 more
europepmc   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Synergistic prognostic value of transcription factor multiplicity and Ki-67 in pituitary neuroendocrine tumour recurrence after endoscopic transsphenoidal surgery: a novel tiered molecular risk model. [PDF]

Front Endocrinol (Lausanne)
Taracha D, Ma H, Nanyama BM, Wang Z, Oshru MIJ, Nziza E, Ali B, Guo H.   +7 more
europepmc   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Development of a Consensus-Based Risk Stratification Algorithm for HR+/HER2- Early Breast Cancer to Guide Adjuvant CDK4/6i Therapy: Outcomes from a Multidisciplinary Workshop in India. [PDF]

Breast Cancer (Dove Med Press)
Mallavarapu KM, Reddy B R, Sp S, Goyal P, Sathyanarayanan V, Rauthan A, Bajpai J, Bhargava PG, Agarwal M, Pinninti R, Chennamaneni R, Chaitanya P K, Bala SC, Pydi VR, Dev R, Dattatreya PS, Batra U, K GB, Shetty D, Paul K, Rathi P, Basade M.   +21 more
europepmc   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source