Results 21 to 30 of about 364,318 (243)

Künstliche Intelligenz in der Literaturrecherche

Bibliothek
Künstliche Intelligenz sieht Muster, die dem Menschen verborgen bleiben, und die Beschäftigung damit fasziniert ihn. Der Artikel untersucht, in welchem Maß diese Mustererkennung auf die Literatursuche umgesetzt werden kann.
Walder Anton
doaj   +1 more source

Dr. rer. oec. Katja Gehrke

Monitor Versorgungsforschung
Die Nutzung von Daten für die medizinische Versorgung ist ein Trend, der das Gesundheitssystem in den nächsten Jahren nachhaltig verändern wird. „Gesundheitsdaten befeuern das lernende Gesundheitssystem der Zukunft“ wurde bereits 2019 prognostiziert und ...
Dr. rer. oec. Katja Gehrke, Prof. Dr. phil. Andreas Meusch   +1 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Increased rates of unattained developmental milestones among Israeli children between 2016 and 2020: a national report

Israel Journal of Health Policy Research, 2023
Background The early years of children’s lives are critical for their healthy development. Although children’s growth and development rates may vary, a significant delay during early childhood could indicate a medical or a developmental disorder ...
Irena Girshovitz, Guy Amit, Inbal Goldshtein, Deena R. Zimmerman, Ravit Baruch, Pinchas Akiva, Meytal Avgil Tsadok, Yair Sadaka   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

smartCasaplus – ein risikobasiertes geriatrisches Gesundheitscoaching für multimorbide Versicherte

Monitor Versorgungsforschung
Das geriatrische Schulungsprogramm Casaplus der MedicalContact AG bietet bereits seit 2007 telefonische Gesundheitscoachings für multimorbide geriatrische Versicherte, von dem bereits ca. 30.000 Versicherte profitiert haben.
Prof. Dr. rer. pol. Stephan Burger, Markus M. Müller MA, Prof. Dr.-Ing. Thomas P. Zahn   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Variability and estimating in fruiting of shea tree (Vitellaria paradoxa C.F. Gaertn) associated to climatic conditions in West Africa: implications for sustainable management and development

Plant Production Science, 2019
Shea tree (Vitellaria paradoxa) is one of the main native oil plants with high economic value in Africa. Its fruits are used for food, medicinal, cultural and exportation purposes. However, the lack of efficient tools to assess annual fruit production of
Loyapin Bondé, Oumarou Ouédraogo, Issaka Ouédraogo, Adjima Thiombiano, Joseph I. Boussim   +4 more
doaj   +1 more source