Results 41 to 50 of about 364,318 (243)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

La caricature des démocraties africaines avant et après la baule dans le parachutage et en attendant le vote des bêtes sauvages. [PDF]

open access: yesPensées Genre, Penser Autrement, 2022
Cette réflexion porte sur la présence d’éléments de l’histoire politique de l’Afrique francophone dans la fiction romanesque. Par le truchement de la colonisation, l’Afrique occidentale française (AOF) a épousé des valeurs de son ancien maitre ...
Boulkini COULDIATI, Fatimata NOMBRE
doaj  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

THE EFFICACY OF ZUCLOPENTHIXOL ACETATE IN PSYCHOTIC PATIENTS

open access: yesPsychiatry and Clinical Psychopharmacology, 2021
Fourteen psychotic patients, 7 acute manic and 7 exacerbated patients were included in the study to evaluate the clinical effect of zuclopenthixol acetate in viscoleo. Each patient received 50-200mg. of the drug for the first injection. If necessary the
Nesrin DlLBAZ   +2 more
doaj  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Renu Ki Bharat Ki Khoj

open access: yes, 2021
This article aims at identifying the ideology of the Renu nation. In the new India, Renu clearly saw different challenges ahead of democracy. Worthless to say that autocracy and communalism were the biggest challenge.
openaire   +2 more sources

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

LASER POSTERIOR CAPSULOTOMY IN CASE OF THE 1ST DEGREE OF POSTERIOR CAPSULAR OPACITY OF THE LENS IN PSEUDOPHAKIC EYES

open access: yesОфтальмохирургия, 2015
Purpose. To identify indications for laser posterior capsulotomy in case of the 1st degree of posterior capsular opacity (PCO) of the lens in pseudophakic eyes.Material and methods. The study was carried out in 43 patients (43 eyes) aged 45-74 years old,
A. D. Chuprov   +2 more
doaj  

Inconclusive prospective associations between maternal emotional expressiveness and children’s callous-unemotional traits: a reanalysis and comment on Hu et al. (2026)

open access: yesFrontiers in Psychology
In a recent study, researchers used cross-lagged panel models (CLPM) and concluded prospective associations between maternal emotional expressiveness and children’s callous-unemotional traits. However, it is well established that associations in the CLPM
Kimmo Sorjonen, Bo Melin, Marika Melin
doaj   +1 more source

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