Results 191 to 200 of about 355,596 (243)

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Pharmacokinetic modelling of MRI-based liver function for risk assessment in primary sclerosing cholangitis: a prospective pilot study. [PDF]

Eur Radiol Exp
Bartholomä WC, Cai S, Simonsson C, Karlsson M, Kechagias S, Woisetschläger M, Dahlström N, Lundberg P.   +7 more
europepmc   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Associations Between Apparent Diffusion Coefficient Values and Histopathologic Prognostic Factors in Breast Cancer: A Retrospective Study. [PDF]

Int J Breast Cancer
Mahdavi Sabet F, Zeinalkhani F, Forghani S, Kamali Hakim P, Zeinalkhani H, Tahanian F.   +5 more
europepmc   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Single-domain antibodies as potent inhibitors of clinically relevant <i>β</i>-lactamases in multidrug-resistant bacteria. [PDF]

Front Microbiol
Osset-Trenor P, Proft M, Pascual-Ahuir A.   +2 more
europepmc   +1 more source

Flexoelectricity in Photoconversion: Fundamentals, Materials, and Outlooks

Advanced Science, EarlyView.
Mechanical bending of a flexible cantilever induces a strain gradient in the photoactive material. The resulting flexoelectric field couples with photovoltaic and photoconductive effects, modulating charge generation, separation, and collection. A comparative analysis of oxide perovskites, halide perovskites, and two‐dimensional materials is presented,
Xiang Huang, Feng Li, Rongkun Zheng
wiley   +1 more source

Expression of Estrogen Receptor Alpha and Ki-67 in Synchronous Canine Mammary Tumors. [PDF]

J Mammary Gland Biol Neoplasia
Hansen N, Moberg IM, Solbakken MH, Gunnes G, Borge KS, Arnet EF, Guttersrud OA, Bergholtz H, Lingaas F.   +8 more
europepmc   +1 more source

Surface Fermi Level Modulation of Photoanode by Optimized Conducting Nanoparticle Heterointerfaces for Enhanced Photoelectrochemical Water Splitting

Advanced Science, EarlyView.
Optimizing the heterointerface coverage of the conducting Ni2P nanoparticles on the surface of BVO photoanode manipulates the surface Fermi‐level modulation, which significantly enhances photoelectrochemical oxygen evolution reaction. Our multiscale simulations and experimental results reveal that an optimal Ni2P coverage of 9.4% pins the surface Fermi
Phuong Thi Pham, Seulgi Ji, Unbeom Baeck, Yuankai Li, Duong Nguyen Nguyen, Won Tae Hong, Yang You, John Moraros, Kyoungsuk Jin, Jun Young Lee, Chan‐Hwa Chung, Tae‐Hoon Kim, Jongwook Park, Heechae Choi, Jung Kyu Kim   +14 more
wiley   +1 more source