Results 41 to 50 of about 715,372 (292)

KI - Reizwort oder Wunderwaffe [PDF]

, 2020
Künstliche Intelligenz (KI) als Digitalisierungswerkzeug spielt eine wichtige Rolle für die Analyse von grossen, komplexen und unstrukturierten beziehungsweise uneinheitlichen Datensätzen.
Weber, Regina
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Variability and estimating in fruiting of shea tree (Vitellaria paradoxa C.F. Gaertn) associated to climatic conditions in West Africa: implications for sustainable management and development

Plant Production Science, 2019
Shea tree (Vitellaria paradoxa) is one of the main native oil plants with high economic value in Africa. Its fruits are used for food, medicinal, cultural and exportation purposes. However, the lack of efficient tools to assess annual fruit production of
Loyapin Bondé, Oumarou Ouédraogo, Issaka Ouédraogo, Adjima Thiombiano, Joseph I. Boussim   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Engagement politique des femmes et logiques d’incorporation dans les instances de décision dans la ville de Ouagadougou (Burkina Faso) [PDF]

Pensées Genre, Penser Autrement, 2022
La participation effective des femmes à la vie politique burkinabè est faible et stagnante. Cependant, une catégorie de femmes engagées sont parvenues à tirer leur épingle du jeu.
Sophie Wenninkonté KABRE, Bowendsom Claudine Valérie ROUAMBA/OUEDRAOGO   +1 more
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A NEW APPROACH TO DISINFECTION OF CLEANROOMS (MICROBIOLOGICALLY ASPECTS)

Разработка и регистрация лекарственных средств, 2019
Microbiological studies conducted the effectiveness of surfaces decontamination by using potassium iodide submicron aerosol, made by the device Generator of sea air «Aeroiodine». We used bacteria of the genus Staphylococcus as the test cultures.
N. P. Sachivkina
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Forschungsperspektiven zu KI, Informationsverhalten und Informationskompetenz

Bibliothek
Der vorliegende Beitrag berichtet über Konzept und Ergebnisse eines Workshops der Autor*innen auf der internationalen Konferenz für Informationsverhaltensforschung (ISIC 2024).
Michel Antje, Griesbaum Joachim
doaj   +1 more source