Results 151 to 160 of about 203,911 (336)

Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis. [PDF]

, 2018
Tumour cells are subjected to evolutionary selection pressures during progression from initiation to metastasis. We analysed the clonal evolution of squamous skin carcinomas induced by DMBA/TPA treatment using the K5CreER-Confetti mouse and stage ...
Balmain, Allan, Del Rosario, Reyno, Harris, Sophie, Kandyba, Eve, Reeves, Melissa Q   +4 more
core   +1 more source

Combined quantitative measures of ER, PR, HER2, and KI67 provide more prognostic information than categorical combinations in luminal breast cancer

Modern Pathology, 2019
Although most women with luminal breast cancer do well on endocrine therapy alone, some will develop fatal recurrence thereby necessitating the need to prospectively determine those for whom additional cytotoxic therapy will be beneficial.
M. Abubakar, M. Abubakar, J. Figueroa, H. R. Ali, F. Blows, J. Lissowska, C. Caldas, D. Easton, M. Sherman, M. García-Closas, M. Dowsett, M. Dowsett, P. Pharoah   +12 more
semanticscholar   +1 more source

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source

Pathfinder cells provide a novel therapeutic intervention for acute kidney injury [PDF]

, 2013
Pathfinder cells (PCs) are a novel class of adult-derived cells that facilitate functional repair of host tissue. We used rat PCs to demonstrate that they enable the functional mitigation of ischemia reperfusion (I/R) injury in a mouse model of renal ...
Alan MacIntyre, Alasdair I. MacDonald, Christian Koppelstaetter, David Russell, Herrera MB, Iwatani H, Kathrin Eller, Liane M. McGlynn, Megyesi J, Paul G. Shiels, R.W. Davies, Thakar CV   +11 more
core   +1 more source

The Ki67 dilemma: investigating prognostic cut-offs and reproducibility for automated Ki67 scoring in breast cancer

Breast Cancer Research and Treatment
Abstract Purpose Quantification of Ki67 in breast cancer is a well-established prognostic and predictive marker, but inter-laboratory variability has hampered its clinical usefulness. This study compares the prognostic value and reproducibility of Ki67 scoring using four ...
Emma Rewcastle, Ivar Skaland, Einar Gudlaugsson, Silja Kavlie Fykse, Jan P. A. Baak, Emiel A. M. Janssen   +5 more
openaire   +2 more sources

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Non-Small Cell Lung Cancer in Young Patients: An Analysis of Clinical, Pathologic and TNM Stage Characteristics Compared to the Elderly

Risk Management and Healthcare Policy, 2020
Xin Jin, Xin Zhao, Xingsheng Liu, Ke Han, Gaojun Lu, Yi Zhang Thoracic Surgery Department, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yi ZhangThoracic Surgery Department, Xuanwu Hospital, Capital
Jin X, Zhao X, Liu X, Han K, Lu G, Zhang Y   +5 more
doaj  

Ki67 Immunofluorescence on Bovine Cell Lines

BIO-PROTOCOL, 2013
This is a rapid protocol to test the effects of drugs treatment on bovine cell replication using Ki67 staining. Ki67 is associated with cell proliferation and is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0).
Justine Marsolier, Souhila Medjkane, Martine Perichon, Jonathan Weitzman   +3 more
openaire   +2 more sources

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source

Amine‐Functionalized Chitosan/dECM Composite Promotes Cutaneous Regeneration and Hair Follicle Activation by Regulating Oxidative Stress and Inflammation

Advanced Healthcare Materials, EarlyView.
An amine‐functionalized chitosan and hydrolyzed dECM composite promotes cutaneous regeneration by modulating oxidative stress and inflammatory pathways. The material accelerates wound closure and stimulates hair follicle activation in UV‐damaged cutaneous tissue.
Yu‐Jin Kim, Seokheon Hong, Jae Hwi Lee, Jongmin Lee, Jae Jun Kang, Jiseon Bae, Jino Kim, Dong‐Hwee Kim, Jin Yoo, Mi Sun Cha, Su Hee Kim, Youngmee Jung   +11 more
wiley   +1 more source