Results 261 to 270 of about 203,911 (336)

Human eosinophils exert antitumorigenic effects on chordoma. [PDF]

Chin Neurosurg J
Ying W, Peng L, Jingqiao B, Lingzhi X, Yuan R, Pinan L, Bo W.   +6 more
europepmc   +1 more source

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source

Morphological and transcriptomic change of brain pericytes by lipopolysaccharide treatment. [PDF]

Front Neural Circuits
Asai T, Yonezu Y, Uyeda A, Watanabe H, Suzuki T, Misawa H, Muramatsu R.   +6 more
europepmc   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

Associations of the HER2DX Genomic Test with Biological and Pathologic Features in HER2-Positive Breast Cancer. [PDF]

Clin Cancer Res
Sanfeliu E, Martínez-Romero A, Marín-Aguilera M, Cobo S, González-Farré B, Hernandez-Illan E, Jares P, Puig-Butillé JA, Muñoz M, Gómez-Bravo R, Tapia M, Tebar C, Saura C, Escrivà-de-Romaní S, Soberino J, Cortés J, Morales S, Amillano K, Paré L, Villagrasa P, Buckingham W, Pardo F, Parker JS, Brasó-Maristany F, Ciruelos E, Sánchez-Bayona R, Martinez-Sáez O, Cejalvo JM, Prat A.   +28 more
europepmc   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Generation of Mice Harboring Bicc1 Conditional Null Alleles. [PDF]

Genesis
Liu CF, Leon S, Herrig I, Wessely O, Tang WHW.   +4 more
europepmc   +1 more source

Integrated Microfluidic Platform for High‐Throughput Generation of Intestinal Organoids in Hydrogel Droplets

Advanced Science, EarlyView.
ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova, Hannah Kronabitter, Mar Cervera‐Negueruela, Eylul Ceylan, Laura Benito‐Zarza, Rubén López‐Sandoval, Irineja Cubela, J. Gray Camp, Jose L. Garcia‐Cordero   +8 more
wiley   +1 more source

Primary renal neuroendocrine tumor combined with horseshoe kidney: a case report and review of the literature. [PDF]

BMC Urol
Ni J, Wu S, Ding X, Zhou G.
europepmc   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source