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Ki67 targeted strategies for cancer therapy
Clinical and Translational Oncology, 2017Ki67 is a well-known proliferation marker for the evaluation of cell proliferation. Numerous studies have indicated that Ki67 index independently predicts cancer progression. Moreover, because Ki67 is highly expressed in malignant cells but almost could not be detected in normal cells, it has become a promising target for cancer therapy. In this review,
L Mao
exaly +3 more sources
Ki67 protein: the immaculate deception?
Histopathology, 2002Ki67 protein: the immaculate deception? This article updates our previous review of Ki67 published in Histopathology 10 years ago. In this period the numbers of papers published featuring this antibody has increased 10‐fold from 338 to 3489 indicating the considerable enthusiasm with which this antibody has been studied.
D C, Brown, K C, Gatter
exaly +4 more sources
Significance of Ki67 expression in endometriosis for infertility
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2022The aim of the study was to show the significance of Ki67 expression in endometriosis for infertility.It was a retrospective analysis. 670 cases were analyzed. In 484 cases, immunohistochemical proliferation analysis was performed to determine the expression of Ki67. The indicated percentages of Ki67 expression were divided into three groups.
Elvin, Piriyev +3 more
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Cancer Investigation, 2008
We examined Ki67 expression in salivary malignancies of 75 patients with a follow-up period of up to 20 years. Correlations between enhanced Ki67 and enhanced p53 and TUNEL and heparanase staining levels were significant. Median survival for reduced-stained-tumor patients (< or = 5%) was 163 months, dropping significantly to 39 months (p = 0.0005) for ...
Ofer, Ben-Izhak +2 more
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We examined Ki67 expression in salivary malignancies of 75 patients with a follow-up period of up to 20 years. Correlations between enhanced Ki67 and enhanced p53 and TUNEL and heparanase staining levels were significant. Median survival for reduced-stained-tumor patients (< or = 5%) was 163 months, dropping significantly to 39 months (p = 0.0005) for ...
Ofer, Ben-Izhak +2 more
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P53 and Ki67 in Adrenocortical Tumors
Endocrine Research, 2000The p53 tumor-supressor gene has been reported as the most frequent genetic abnormality seen in human malignancies. Here we studied immunohistochemically the expression of p53 in a large series of adrenocortical tumors. The proliferative activity was assessed by the expression of Ki67.
J, Arola +4 more
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A Scoring Method for Immunohistochemical Staining on Ki67
Applied Immunohistochemistry & Molecular Morphology, 2020An accurate interpretation of immunohistochemistry (IHC) staining results is crucial for precise disease diagnosis. In this study, we present a novel scoring method for interpreting and reporting of IHC staining assay results for the nuclear-type molecule.
Rui, Guo +5 more
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Ki67 and proliferation in breast cancer
Journal of Clinical Pathology, 2013New approaches to the prognostic assessment of breast cancer have come from molecular profiling studies. A major feature of this work has been to emphasise the importance of cancer cell proliferation as a key discriminative indicator of recurrence risk for oestrogen receptor positive breast cancer in particular. Mitotic count scoring, as a component of
Nirmala, Pathmanathan +1 more
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Proliferation of trophoblasts and Ki67 expression in preeclampsia
Archives of Gynecology and Obstetrics, 2014Preeclampsia is a pregnancy-specific disease with the increased risk of maternal morbidity and mortality. It is characterised by placental vascular dysfunction. Despite the numerous studies on preeclampsia, studies evaluating proliferation of villous trophoblasts in preeclamptic placentas are limited.
Barış, Kaya +6 more
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Ki67 Labeling Correlated With Invasion But Not With Recurrence
Applied Immunohistochemistry & Molecular Morphology, 2017Pituitary adenomas account for 10% to 15% of intracranial neoplasms. Multiple factors had been introduced for tumor recurrence. MIB-1 monoclonal antibody, a marker of the proliferative index, has been introduced in various tumors, but unfortunately, the usefulness of MIB-1 in predicting the behavior of pituitary adenoma has been debated recently. Hence,
Alireza, Sadeghipour +7 more
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Ki67 assessment in breast cancer: an update
Pathology, 2017Although immunohistochemical detection of the Ki67 antigen has been used for many years to assess cancer proliferation, this marker is still not recommended for routine use in clinical management of breast cancer. The major reason for this situation is a lack of a standardised procedure for Ki67 assessment as well as persistence of several issues of ...
Penault-Llorca, Frédérique +1 more
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