Results 61 to 70 of about 29,081 (306)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Insights from a Brief Study of Renal Calculi: Recent Diagnostic and Treatment Approaches

Journal of Bio-X Research
Background: Renal calculi, commonly known as kidney stones, is a prevalent urological condition that affects a substantial portion of the population worldwide.
Aashish Kumar, Rajat Goyal, Kajal Garg, Sumeet Gupta, Kashish Wilson, Hitesh Chopra   +5 more
doaj   +1 more source

Addition of Sodium Bicarbonate to Irrigation Solution May Assist in Dissolution of Uric Acid Fragments During Ureteroscopy [PDF]

, 2018
Introduction: We hypothesized that adding sodium bicarbonate (bicarb) to normal saline (NS) irrigation during ureteroscopy in patients with uric acid (UA) nephrolithiasis may assist in dissolving small stone fragments produced during laser lithotripsy ...
Lingeman, James E., Paonessa, Jessica E., Williams, James C., Jr.   +2 more
core   +1 more source

[Potassium determinations in kidney calculi].

MMW, Munchener medizinische Wochenschrift, 1974
MMW Munch Med ...
Pfau, A., Kallistratos, G., Fenner, O.
openaire   +2 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Morpho-constitutional analysis of urolithiasis and in vitro litholytic evaluation of select plants against diverse renal calculi variants

African Journal of Urology
Background This study explores the potential litholytic activity of medicinal plant infusions, specifically Arenaria rubra, Hordeum vulgare, and Zea mays, as well as a combination of these infusions, on various types of urinary calculi.
Abdelaali Belhachem, S. Makhloufi, R. Lecheheb, D. Mediouni, A. Bennekrouf, A. Amiar, A. Bengueddach, W. Belkacem, F. Boudia, M. J. Yousfi, H. Toumi   +10 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Peri-Operative Factors Affecting Blood Transfusion Requirements During PCNL: A Retrospective Non-Randomized Study

Research and Reports in Urology, 2020
Chinnakhet Ketsuwan, Narutsama Pimpanit, Yada Phengsalae, Charoen Leenanupunth, Wisoot Kongchareonsombat, Premsant Sangkum Division of Urology, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok ...
Ketsuwan C, Pimpanit N, Phengsalae Y, Leenanupunth C, Kongchareonsombat W, Sangkum P   +5 more
doaj  

Obesity and kidney stone disease. A systematic review [PDF]

, 2018
INTRODUCTION: Currently, abdominal obesity has reached an epidemic stage and obesity represents an important challenge for worldwide health authorities. Epidemiologic studies have demonstrated that the stone risk incidence increases with Body Mass Index,
AL SALHI, Yazan, Bozzini, Giorgio, Carbone, Antonio, DE NUNZIO, Cosimo, Fuschi, Andrea, Mazzaferro, Sandro, Palleschi, Giovanni, Pastore, ANTONIO LUIGI, Tasca, Andrea   +8 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source