Results 91 to 100 of about 1,036,066 (335)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Albuminuria, Kidney Function, and Cancer Risk in the Community [PDF]

, 2020
Yejin Mok, Shoshana H. Ballew, Yingying Sang, Josef Coresh, Corinne E. Joshu, Elizabeth A. Platz, Kunihiro Matsushita   +6 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Renal parenchymal volume analysis: Clinical and research applications

BJUI Compass
Background and Objectives In most patients, the renal parenchymal volumes in each kidney directly correlate with function and can be used as a proxy to determine split renal function (SRF).
Carlos Munoz‐Lopez, Kieran Lewis, Nityam Rathi, Eran Maina, Akira Kazama, Anne Wong, Angelica Bartholomew, Worapat Attawettayanon, Yunlin Ye, Zhiling Zhang, Wen Dong, Rebecca A. Campbell, Nicholas Heller, Erick Remer, Christopher Weight, Steven C. Campbell   +15 more
doaj   +1 more source

The use of urinary proteomics in the assessment of suitability of mouse models for ageing [PDF]

, 2017
Ageing is a complex process characterised by a systemic and progressive deterioration of biological functions. As ageing is associated with an increased prevalence of age-related chronic disorders, understanding its underlying molecular mechanisms can ...
Bajwa, Seerat, Bascands, Jean-Loup, Bechtel-Walz, Wibke, Borries, Melanie, Busch, Hauke, Dray, Cédric, Huber, Tobias B., Koeck, Thomas, Mischak, Harald, Nkuipou-Kenfack, Esthet, Pejchinovski, Martin, Pich, Andreas, Rudolph, Karl L., Schanstra, Joost P., Valet, Philippe, Vinel, Claire, Vlahou, Antonia, Zürbig, Petra   +17 more
core   +3 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

OP01 Hypertension and risk of cancers of the kidney and urinary tract in UK women [PDF]

, 2020
Kezia Gaitskell, Sarah Floud, BJ Cairns, Kirstin Pirie, Isobel Barnes, J Green, Valerie Beral, GK Reeves   +7 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Unconventional machine learning of genome-wide human cancer data

, 2020
Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex aberrant molecular underpinnings of human disease from a genome-wide perspective ...
Bajaj, Sweta R., Chittenden, Thomas W., Cilfone, Nicholas, Gamel, Omar E., Gujja, Sharvari, Gulcher, Jeffrey R., Li, Richard Y., Lidar, Daniel A.   +7 more
core   +1 more source