Results 151 to 160 of about 1,749,999 (379)

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Renal Parenchymal Area and Kidney Collagen Content [PDF]

arXiv, 2016
The extent of renal scarring in chronic kidney disease (CKD) can only be ascertained by highly invasive, painful and sometimes risky tissue biopsy. Interestingly, CKD-related abnormalities in kidney size can often be visualized using ultrasound. Nevertheless, not only does the ellipsoid formula used today underestimate true renal size but also the ...
arxiv  

On the Pathology of the Morbid State Commonly Called Chronic Bright's Disease with Contracted Kidney. (“Arterio-Capillary Fibrosis.”) [PDF]

, 1872
William Gull, Henry G. Sutton
openalex   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Comparations of efficacy and safety of rituximab, calcineurin inhibitors and cyclophosphamide in primary membranous nephropathy: a single-center retrospective analysis

BMC Nephrology
Background To compare the efficacy and safety of rituximab (RTX), calcineurin inhibitor (CNI) and cyclophosphamide (CTX) plus glucocorticoids in the treatment of primary membranous nephropathy (PMN).
Luying Lu, Shasha Cai, Huayan Zhu, Guangjun Liu, Yaomin Wang, Pingping Ren, Lan Lan, Xiaoqi Shen, Liangliang Chen, Ying Xu, Jun Cheng, Xiayu Li, Jianghua Chen, Fei Han   +13 more
doaj   +1 more source

A Practical Treatise on Brightʼs Disease of the Kidneys [PDF]

, 1872
T Grainger Stewart
openalex   +1 more source

Supporting science studies for children with long term health problems using Nefreduca [PDF]

, 2010
Children with long term health problems cannot always maintain their schooling and keep up with the curriculum (Prevatt et al., 2000; McDougall et al., 2004). They also spend prolonged periods in hospital where access to science teaching is very limited (
Pinto, Roser, Saez, Marcella, Whitelock, Denise   +2 more
core  

Narrative Review of Incremental Hemodialysis. [PDF]

, 2020
The prescription of hemodialysis (HD) in patients with incident end-stage kidney disease (ESKD) is fundamentally empirical. The abrupt transition from nondialysis chronic kidney disease (CKD) to thrice-weekly in-center HD of much the same dialysis ...
Garneata, Liliana, Kalantar-Zadeh, Kamyar, Moossavi, Shahriar, Murea, Mariana   +3 more
core  

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Monocytes prevent apoptosis of iPSCs and promote differentiation of kidney organoids

Stem Cell Research & Therapy
Background Induced pluripotent stem cells (iPSCs)-derived kidney organoids are a promising model for studying disease mechanisms and renal development. Despite several protocols having been developed, further improvements are needed to overcome existing ...
Ekaterina Pecksen, Sergey Tkachuk, Cristoph Schröder, Marc Vives Enrich, Anindita Neog, Cory P. Johnson, Niko Lachmann, Hermann Haller, Yulia Kiyan   +8 more
doaj   +1 more source