Results 21 to 30 of about 2,119,577 (353)

Association Between Syndecan-1, Fluid Overload, and Progressive Acute Kidney Injury After Adult Cardiac Surgery

Frontiers in Medicine, 2021
Background: Acute kidney injury (AKI) is a common complication after cardiac surgery and the prognosis of AKI worsens with the increase in AKI severity. Syndecan-1(SDC-1) is a biomarker of endothelial glycocalyx degradation.
Jiarui Xu, Jiarui Xu, Wuhua Jiang, Wuhua Jiang, Yang Li, Yang Li, Haoxuan Li, Haoxuan Li, Xuemei Geng, Xuemei Geng, Xin Chen, Xin Chen, Jiachang Hu, Jiachang Hu, Bo Shen, Bo Shen, Yimei Wang, Yimei Wang, Yi Fang, Yi Fang, Chunsheng Wang, Zhe Luo, Guowei Tu, Jie Hu, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding, Jie Teng, Jie Teng, Jie Teng, Xialian Xu, Xialian Xu   +31 more
doaj   +1 more source

Climate change and the kidney [PDF]

, 2019
The worldwide increase in temperature has resulted in a marked increase in heat waves (heat extremes) that carries a markedly increased risk for morbidity and mortality.
Butler-Dawson, Jaime, Diaz, Henry F., Garcia, Gabriela, Hernando, Ana Andres, Johnson, Richard J., Lanaspa, Miguel A., Lemery, Jay, Newman, Lee S., Rodriguez-Iturbe, Bernardo, Roncal-Jimenez, Carlos A., Sato, Yuka, Sánchez-Lozada, Laura G., Tolan, Dean R.   +12 more
core   +1 more source

Renal hemosiderosis presenting with acute kidney Injury and macroscopic hematuria in Immunoglobulin A nephropathy: a case report

BMC Nephrology, 2021
Background Macroscopic hematuria-associated acute kidney injury (AKI) is a well-known complication of immunoglobulin A (IgA) nephropathy. In such cases, intratubular obstruction by red blood cell (RBC) casts and acute tubular necrosis are mainly observed
Shinya Taguchi, Sumi Hidaka, Mitsuru Yanai, Kunihiro Ishioka, Kenji Matsui, Yasuhiro Mochida, Hidekazu Moriya, Takayasu Ohtake, Shuzo Kobayashi   +8 more
doaj   +1 more source

Chronic kidney disease [PDF]

The Lancet, 2021
Chronic kidney disease is a progressive disease with no cure and high morbidity and mortality that occurs commonly in the general adult population, especially in people with diabetes and hypertension. Preservation of kidney function can improve outcomes and can be achieved through non-pharmacological strategies (eg, dietary and lifestyle adjustments ...
Kalantar-Zadeh, Kamyar, Jafar, Tazeen H, Nitsch, Dorothea, Neuen, Brendon L, Perkovic, Vlado   +4 more
openaire   +4 more sources

Chronic Kidney Disease

Disease-a-Month, 2015
In his review article in the March 2015 edition ofCME, Prof. A M Meyers refers to chronic kidneydisease as 'an important disease group that threatenshealth'. I fully concur with this observation andwish to go a step further and assert that kidneydisease, together with other related non-communicable diseases(NCDs), poses not only a threat to health but ...
Catherine E. Langston, Adam E. Eatroff
  +8 more sources

Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in ...
Arcaro, Alexandre, Castelletti, Deborah, Fu, Xuebin, Liu, Yang, Mischak, Harald, Mullen, William, Pejchinovski, Martin, Serra, Andreas L., Siwy, Justyna, Wang, Xueqi, Watnick, Terry J.   +10 more
core   +2 more sources

Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases

Renal Failure, 2018
Background: Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells ...
Yuanyuan Li, Xueyong Liu, Wei Wang, Shaohua Wang, Jianchun Zhang, Song Jiang, Yang Wang, Liping Li, Jinghua Li, Youkang Zhang, Haichang Huang   +10 more
doaj   +1 more source

Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury

Cell Death and Disease, 2023
An important pathophysiological process of acute kidney injury (AKI) is mitochondrial fragmentation in renal tubular epithelial cells, which leads to cell death.
Wenjia Xie, Qingyun He, Yan Zhang, Xinxin Xu, Ping Wen, Hongdi Cao, Yang Zhou, Jing Luo, Junwei Yang, Lei Jiang   +9 more
doaj   +1 more source

Effect of a reduction in glomerular filtration rate after nephrectomy on arterial stiffness and central hemodynamics: rationale and design of the EARNEST study [PDF]

, 2014
Background: There is strong evidence of an association between chronic kidney disease (CKD) and cardiovascular disease. To date, however, proof that a reduction in glomerular filtration rate (GFR) is a causative factor in cardiovascular disease is ...
Alam, Arena, Bahous, Benetos, Blacher, Blacher, Boudville, Briet, Charles J. Ferro, Charles R. Tomson, Chue, Chue, Daniel Zehnder, DeLoach, Doucende, Edwards, Eknoyan, Faul, Fehrman-Ekholm, Foley, Forbat, Frimodt-Moller, Garg, Go, Groenink, Grothues, Guerin, Hametner, Ian B. Wilkinson, Ibrahim, Jackson, John R. Cockcroft, Jonathan N. Townend, Kasiske, Krohn, Landray, Lang, Laurent, Laurie A. Tomlinson, Levey, Lewington, Luzardo, Maceira, Madero, Mafham, Mark, Martensson, Matsushita, Michels, Moody, Moody, Myerson, Nagueh, National Kidney Foundation, O'Brien, Patrick B. Mark, Richard P. Steeds, Rook, Rothwell, Savage, Schiffrin, Schiller, Segev, Tavakol, Townsend, Vickery, Wang, Wei, Weiss, Wiesmann, Wilkinson, William E. Moody, Yeon, Young   +73 more
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The Association of Syndecan-1, Hypercoagulable State and Thrombosis and in Patients With Nephrotic Syndrome

Clinical and Applied Thrombosis/Hemostasis, 2021
The aim of this study is to investigate whether Syndecan-1 (SDC-1), an indicator of endothelial glycocalyx injury, would increase the risk of hypercoagulable state and thrombosis in patients with nephrotic syndrome (NS).
Xin Chen, Xuemei Geng, Shi Jin, Jiarui Xu, Man Guo, Daoqi Shen, Xiaoqiang Ding, Hong Liu, Xialian Xu   +8 more
doaj   +1 more source