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Kidney: polycystic kidney disease [PDF]

WIREs Developmental Biology, 2014
Polycystic kidney disease (PKD) is a life‐threatening genetic disorder characterized by the presence of fluid‐filled cysts primarily in the kidneys. PKD can be inherited as autosomal recessive (ARPKD) or autosomal dominant (ADPKD) traits. Mutations in either the PKD1 or PKD2 genes, which encode polycystin 1 and polycystin 2, are the underlying cause of
Binu M, Paul, Gregory B, Vanden Heuvel
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Polycystic Kidney Disease [PDF]

New England Journal of Medicine, 1989
The Polycystic Kidney Disease (PKD) is a genetic disease which is characterized by the gradual emergence of cystic lesions in the kidneys, which replace the renal parenchyma causing deterioration of its function to stage 5. The PKD is one of the causes of Chronic Kidney Disease on renal replacement therapy (RRT).
Lavie, C.J., Klein, A.L., Seward, J.B., Tajik, A.J.   +3 more
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Bone Disease in Chronic Kidney Disease and Kidney Transplant

Nutrients, 2022
Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) comprises alterations in calcium, phosphorus, parathyroid hormone (PTH), Vitamin D, and fibroblast growth factor-23 (FGF-23) metabolism, abnormalities in bone turnover, mineralization, volume, linear growth or strength, and vascular calcification leading to an increase in bone fractures and ...
Bellorin-Font, Ezequiel, Rojas, Eudocia, Martin, Kevin J.   +2 more
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CD74 in Kidney Disease [PDF]

Frontiers in Immunology, 2015
CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT/MIF-2). CD74 expression is increased in tubular cells and/or glomerular podocytes and parietal cells in human metabolic nephropathies, polycystic kidney disease, graft rejection and kidney ...
Lara eValiño-Rivas, Ciro eBaeza-Bermejillo, Laura eGonzalez-Lafuente, Ana eSanz, Alberto eOrtiz, Alberto eOrtiz, Alberto eOrtiz, Maria D Sanchez-Niño   +7 more
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Association Between Syndecan-1, Fluid Overload, and Progressive Acute Kidney Injury After Adult Cardiac Surgery

Frontiers in Medicine, 2021
Background: Acute kidney injury (AKI) is a common complication after cardiac surgery and the prognosis of AKI worsens with the increase in AKI severity. Syndecan-1(SDC-1) is a biomarker of endothelial glycocalyx degradation.
Jiarui Xu, Jiarui Xu, Wuhua Jiang, Wuhua Jiang, Yang Li, Yang Li, Haoxuan Li, Haoxuan Li, Xuemei Geng, Xuemei Geng, Xin Chen, Xin Chen, Jiachang Hu, Jiachang Hu, Bo Shen, Bo Shen, Yimei Wang, Yimei Wang, Yi Fang, Yi Fang, Chunsheng Wang, Zhe Luo, Guowei Tu, Jie Hu, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding, Jie Teng, Jie Teng, Jie Teng, Xialian Xu, Xialian Xu   +31 more
doaj   +1 more source

Is “chronic kidney disease” a disease? [PDF]

Journal of Evaluation in Clinical Practice, 2018
AbstractSeveral philosophers of medicine have attempted to answer the question “what is disease?” In current clinical practice, an umbrella term “chronic kidney disease” (CKD) encompasses a wide range of kidney health states from commonly prevalent subclinical, asymptomatic disease to rare end‐stage renal disease requiring transplant or dialysis to ...
Smart, B, Stevens, R, Verbakel, J
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Trametenolic Acid Ameliorates the Progression of Diabetic Nephropathy in db/db Mice via Nrf2/HO-1 and NF-κB-Mediated Pathways

Journal of Immunology Research, 2022
Diabetic nephropathy (DN) is a fatal complication of diabetes and the main cause of end-stage renal disease. Due to the suboptimal effects of current treatments, there is an urgent need to develop new therapeutic strategies for DN. Trametenolic acid (TA),
Qi Duan, Lingling Tian, Jiabing Feng, Xinbo Ping, Lihong Li, Hasnaa Yaigoub, Rongshan Li, Yafeng Li   +7 more
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Renal hemosiderosis presenting with acute kidney Injury and macroscopic hematuria in Immunoglobulin A nephropathy: a case report

BMC Nephrology, 2021
Background Macroscopic hematuria-associated acute kidney injury (AKI) is a well-known complication of immunoglobulin A (IgA) nephropathy. In such cases, intratubular obstruction by red blood cell (RBC) casts and acute tubular necrosis are mainly observed
Shinya Taguchi, Sumi Hidaka, Mitsuru Yanai, Kunihiro Ishioka, Kenji Matsui, Yasuhiro Mochida, Hidekazu Moriya, Takayasu Ohtake, Shuzo Kobayashi   +8 more
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Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases

Renal Failure, 2018
Background: Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells ...
Yuanyuan Li, Xueyong Liu, Wei Wang, Shaohua Wang, Jianchun Zhang, Song Jiang, Yang Wang, Liping Li, Jinghua Li, Youkang Zhang, Haichang Huang   +10 more
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Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury

Cell Death and Disease, 2023
An important pathophysiological process of acute kidney injury (AKI) is mitochondrial fragmentation in renal tubular epithelial cells, which leads to cell death.
Wenjia Xie, Qingyun He, Yan Zhang, Xinxin Xu, Ping Wen, Hongdi Cao, Yang Zhou, Jing Luo, Junwei Yang, Lei Jiang   +9 more
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