Results 71 to 80 of about 2,023,116 (304)

The immune cell landscape in kidneys of patients with lupus nephritis. [PDF]

, 2019
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control
Accelerating Medicines Partnership in SLE network, Anolik, Jennifer H, Apruzzese, William, Arazi, Arnon, Berthier, Celine C, Brenner, Michael B, Browne, Edward P, Buyon, Jill P, Chicoine, Adam, Dall'Era, Maria, Davidson, Anne, Diamond, Betty, Eisenhaure, Thomas M, Furie, Richard A, Hacohen, Nir, Hildeman, David A, Hoover, Paul J, Jonsson, A Helena, Kalunian, Kenneth C, Kamen, Diane L, Kretzler, Matthias, Lederer, James A, Li, Shuqiang, Lieb, David J, Liu, Yanyan, Massarotti, Elena, McInnis, Elizabeth A, Noma, Akiko, Nusbaum, Chad, Park, Meyeon, Payan-Schober, Fernanda, Pendergraft, William F, Petri, Michelle A, Putterman, Chaim, Rao, Deepak A, Raychaudhuri, Soumya, Slowikowski, Kamil, Smilek, Dawn E, Steelman, Scott, Sutherby, Danielle, Tosta, Patti, Wofsy, David, Woodle, E Steve, Zhang, Fan   +43 more
core  

Collaborating to develop an online resource for parents [PDF]

, 2017
Background The development and evaluation of Online Parent Information and Support (OPIS) involved the creation of a web resource for parents who needed support for the home-based management of their child's chronic kidney disease (CKD)
Smith, T., Stephenson, M., Swallow, Veronica   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Relationship between mortality and Geriatric Nutritional Risk Index (GNRI) at the time of dialysis initiation: a prospective multicenter cohort study

Renal Replacement Therapy, 2017
Background The Geriatric Nutritional Risk Index (GNRI) is a nutritional screening method primarily developed for elderly people; it is also reported to be useful for predicting mortality in patients on maintenance dialysis. However, it is unclear whether
Akihito Tanaka, Daijo Inaguma, Hibiki Shinjo, Minako Murata, Asami Takeda   +4 more
doaj   +1 more source

Impact of parathyroidectomy on left ventricular function in end stage renal disease patients

BMC Nephrology, 2020
Background Secondary hyperparathyroidism (SHPT) is a common complication in end-stage renal disease (ESRD) patients, and parathyroidectomy (PTX) is an effective treatment intervention of SHPT.
Shaohua Chen, Kaixiang Sheng, Ying Shen, Hua Jiang, Xin Lei, Lihui Qu, Chunping Xu, Jianghua Chen, Ping Zhang   +8 more
doaj   +1 more source

Transcript Engineered Extracellular Vesicles Alleviate Alloreactive Dynamics in Renal Transplantation

Advanced Science, 2022
Direct contact of membrane molecules and cytokine interactions orchestrate immune homeostasis. However, overcoming the threshold of distance and velocity barriers, and achieving adhesion mediated immune interaction remain difficult. Here, inspired by the
Jinwen Lin, Junhao Lv, Shiping Yu, Ying Chen, Huiping Wang, Jianghua Chen   +5 more
doaj   +1 more source

The association of preoperative cardiac stress testing with 30-day death and myocardial infarction among patients undergoing kidney transplantation [PDF]

, 2019
BACKGROUND:Although periodic cardiac stress testing is commonly used to screen patients on the waiting list for kidney transplantation for ischemic heart disease, there is little evidence to support this practice.
Alhamad, Tarek, Brown, David L, Dunn, Tim, Novak, Eric, Rich, Michael W, Saeed, Mohammed J, Shpigel, Adam, Stwalley, Dustin   +7 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Predictors of culture-negative peritoneal dialysis-associated peritonitis: a single center, retrospective study

Renal Replacement Therapy, 2023
Background Empirical antibiotic treatment against peritoneal dialysis (PD)-related peritonitis should be immediately initiated before PD effluent culture results are obtained.
Hisato Shima, Takuya Okamoto, Manabu Tashiro, Tomoko Inoue, Seiichiro Wariishi, Hiroyasu Bando, Hiroyuki Azuma, Naohito Iwasaka, Takuji Ohara, Toshio Doi, Kazuyoshi Okada, Jun Minakuchi   +11 more
doaj   +1 more source

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +2 more sources