Results 191 to 200 of about 552,750 (375)

Estimand framework development for eGFR slope estimation and comparative analyses across various estimation methods [PDF]

arXiv
Chronic kidney disease (CKD) is a global health challenge characterized by progressive kidney function decline, often culminating in end-stage kidney disease (ESKD) and increased mortality. To address the limitations such as the extended trial follow-up necessitated by the low incidence of kidney composite endpoint, the eGFR slope -- a surrogate ...
arxiv  

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

Proceedings of the National Academy of Sciences of the United States of America, 2011
Yun-Hee Choi, A. Suzuki, Sachin S Hajarnis, Zhendong Ma, Hannah C. Chapin, M. Caplan, M. Pontoglio, S. Somlo, P. Igarashi   +8 more
semanticscholar   +1 more source

Human efferent ductules and epididymis display unique cell lineages with motile and primary cilia

Andrology, Volume 13, Issue 4, Page 894-910, May 2025.
Abstract Background Previous research has illustrated the role of cilia as mechanical and sensory antennae in various organs within the mammalian male reproductive system across different developmental stages. Despite their significance in both organ development and homeostasis, primary cilia in the human male reproductive excurrent duct have been ...
Ludovic Vinay, Rex A. Hess, Clémence Belleannée   +2 more
wiley   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, EarlyView.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

Partial agenesis of the corpus callosum: Prenatal ultrasound characteristics, associations, and outcome

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Abnormal cavum septi pellucidi is the most common indirect sign of partial agenesis of corpus callosum (pACC). A cystic mass in the midline that communicates with the third ventricle may be an indirect sign of pACC. PACC is highly associated with intra‐ and extracranial malformations.
Changrong Zhou, Hezhou Li, Ruizheng Han, Hongrui Ren, Bin Shen, Xinxia Wang, Fangfang Feng, Mengmeng Wang, Ling Liu   +8 more
wiley   +1 more source

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

CONGENITAL ANOMALIES OF THE KIDNEYS AND URINARY TRACT IN CHILDREN

Zdravniški Vestnik, 2015
Congenital anomalies of the kidney and urinary tract are the commonest congenital anomalies in children, often detected prenatally with ultrasound. This method is useful for assesing the degree of dilatation of the collecting system, structure of the ...
Matjaž Kopač
doaj  

The pharmacokinetics of brensocatib in participants with renal impairment following a single oral administration

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 1191-1197, April 2025.
Aim Brensocatib is an oral, selective, competitive and reversible dipeptidyl peptidase 1 inhibitor in development for the treatment of bronchiectasis. This study evaluated the pharmacokinetics (PKs), safety and tolerability of brensocatib in participants with varying degrees of renal impairment and normal renal function.
Sam Au Yeung, Daniel S. Stein, Thomas C. Marbury, Helen Usansky   +3 more
wiley   +1 more source

“When my mind hurts, my body hurts”: Complex PTSD and chronic physical health conditions—A qualitative study exploring the factors contributing to their relationship

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives Complex PTSD (cPTSD) has a high comorbidity rate with chronic physical health conditions. This is the first qualitative study to investigate what factors might be contributing to this relationship. Methods Twelve participants with cPTSD and chronic physical health conditions were recruited from mental health services across London ...
Laura Blackett, Polly Radcliffe, Teuta Rexhepi‐Johansson, Nicola Reynolds   +3 more
wiley   +1 more source

Echinococcus granulosus antigen B regulates T‐cell function through inhibition of signal transducer and activator of transcription 3 in experimental immune thrombocytopenia

British Journal of Haematology, EarlyView.
During the pathological process of immune thrombocytopenia, signal transducer and activator of transcription 3 (STAT3) is activated by JAKs, leading to the production of a large number of inflammatory cytokines and promoting the activation of Th1, Th2 and Th17 cells.
Yingbin Yue, Yunfei Zhang, Yongfeng Cheng, Hongjie Jiao, Mei Yan   +4 more
wiley   +1 more source