Results 1 to 10 of about 15,419 (219)

Intrafamilial Variability of ADPKD [PDF]

Kidney International Reports, 2019
Introduction Discordance in kidney disease severity between affected relatives is a recognized feature of autosomal dominant polycystic kidney disease (ADPKD).
Korosh Khalili, York Pei, Peter J Margetts   +2 more
exaly   +5 more sources

Feasibility and impact of ketogenic dietary interventions in polycystic kidney disease: KETO-ADPKD—a randomized controlled trial

Cell Reports Medicine, 2023
Summary Ketogenic dietary interventions (KDIs) are beneficial in animal models of autosomal-dominant polycystic kidney disease (ADPKD). KETO-ADPKD, an exploratory, randomized, controlled trial, is intended to provide clinical translation of these ...
Sadrija Cukoski, Christoph Heinrich Lindemann, Sita Arjune   +2 more
exaly   +2 more sources

Cardiovascular Outcomes in Kidney Transplant Recipients With ADPKD

Kidney International Reports, 2022
Introduction Cardiovascular disease leads to high morbidity and mortality in patients with kidney failure. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disease with various cardiac abnormalities.
Dalia Zubidat, Ziad El-Zoghby, Sarah R Senum   +2 more
exaly   +2 more sources

Molecular pathways involved in injury-repair and ADPKD progression

Cellular Signalling, 2020
The major hallmark of Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the formation of many fluid-filled cysts in the kidneys, which ultimately impairs the normal renal structure and function, leading to end-stage renal disease (ESRD).
Chiara Formica, Dorien Peters
exaly   +2 more sources

KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary

Kidney International
The Kidney Disease: Improving Global Outcomes (KDIGO) 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) represents the first KDIGO guideline on this subject.
Ron T Gansevoort, Peter C Harris, Tess Harris   +2 more
exaly   +2 more sources

A distinct bone phenotype in ADPKD patients with end-stage renal disease

Kidney International, 2019
Autosomal dominant polycystic kidney disease (ADPKD) is among the most common hereditary nephropathies. Low bone turnover osteopenia has been reported in mice with conditional deletion of the PKD1 and PKD2 genes in osteoblasts, and preliminary clinical ...
Pieter Evenepoel, Kathleen J Claes, Etienne Cavalier   +2 more
exaly   +2 more sources

ADPedKD: A Global Online Platform on the Management of Children With ADPKD

Kidney International Reports, 2019
Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of renal failure. For several decades, ADPKD was regarded as an adult-onset disease.
Stéphanie De Rechter, Detlef Bockenhauer, Neveen A Soliman   +2 more
exaly   +2 more sources

Clinical practice guideline monitoring children and young people with, or at risk of developing autosomal dominant polycystic kidney disease (ADPKD)

BMC Nephrology, 2019
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is thought to affect about 1 in 1000 people in the UK. ADPKD causes a progressive decline in kidney function, with kidney failure tending to occur in middle age.
Jan Dudley, Paul Winyard, Matko Marlais, Oliver Cuthell, Tess Harris, Jiehan Chong, John Sayer, Daniel P. Gale, Lucy Moore, Kay Turner, Sarah Burrows, Richard Sandford   +11 more
doaj   +2 more sources

A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model

BMC Nephrology, 2018
Background Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients.
Phil McEwan, Hayley Bennett Wilton, Albert C. M. Ong, Bjarne Ørskov, Richard Sandford, Francesco Scolari, Maria-Cristina V. Cabrera, Gerd Walz, Karl O’Reilly, Paul Robinson   +9 more
doaj   +2 more sources

Safety and feasibility of synchronous unilateral nephrectomy and contralateral heminephrectomy for extremely severe autosomal dominant polycystic kidney disease: Techniques and outcome [PDF]

Investigative and Clinical Urology, 2022
Purpose: To demonstrate the safety and feasibility of synchronous unilateral nephrectomy and contralateral heminephrectomy in extremely severe autosomal dominant polycystic kidney disease (ADPKD), which corresponds to the Mayo imaging classification ...
Jang Hee Han, Seung-hwan Jeong, Hyeong Dong Yuk , Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim, Curie Ahn, Chang Wook Jeong   +7 more
doaj   +1 more source