Results 11 to 20 of about 15,419 (219)
Polycystins, ADPKD, and Cardiovascular Disease
Kidney International Reports, 2019 Cardiovascular disorders are the most common cause of mortality in autosomal dominant polycystic kidney disease (ADPKD). This review considers recent clinical and basic science studies that address the contributing factors of cardiovascular dysfunction ...
Ivana Y. Kuo, A. Chapman
semanticscholar +4 more sources
Cardiovascular Manifestations and Management in ADPKD
Kidney International Reports, 2023 Cardiovascular disease (CVD) is the major cause of mortality in autosomal dominant polycystic kidney disease (ADPKD) and contributes to significant burden of disease.
P. Sagar, G. Rangan
semanticscholar +1 more source
Interdisciplinary Journal of Epidemiology and Public Health, 2021 Introducción: la enfermedad poliquística renal autosómica (ADPKD), es considerada huérfana hereditaria. Con una prevalencia mundial de 2.7/100,000 hab. Presenta graves complicaciones con desenlaces fatales.
Juan Sebastian Valencia Quintero +1 more
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Kidney International Reports, 2023 Introduction The course of autosomal dominant polycystic kidney disease (ADPKD) varies greatly among affected individuals, necessitating natural history studies to characterize the determinants and effects of disease progression.
R. Perrone +11 more
semanticscholar +1 more source
Autosomal Dominant Polycystic Kidney Desease Coexisting with Renal Dysplasia. First Case Described and Followed Since Prenatal Period [PDF]
Childhood Kidney Diseases, 2018 Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease and causes terminal chronic renal failure. ADPKD is characterized by bilateral multiple renal cysts, which are produced by mutations of the PKD1 and PKD2 ...
Carmen Truyols
doaj +1 more source
Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD.
Cell Reports, 2023 In autosomal dominant polycystic kidney disease (ADPKD), renal cyst lesions predominantly arise from collecting ducts (CDs). However, relevant CD cyst models using human cells are lacking.
Shin-ichi Mae +15 more
semanticscholar +1 more source
Kidney International, 2023 Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive renal cyst formation that leads to kidney failure. Tolvaptan, a vasopressin 2 receptor (V2R) antagonist, is the only drug approved to treat ADPKD patients with rapid ...
J. Zhou, V. Torres
semanticscholar +1 more source
Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD
Frontiers in Molecular Biosciences, 2022 Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder, which is caused by mutations in the PKD1 and PKD2 genes, characterizing by progressive growth of multiple cysts in the kidneys, eventually leading to end-stage kidney disease ...
Ewud Agborbesong +3 more
semanticscholar +1 more source
Journal of Clinical Medicine, 2022 Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cystic kidney disease, with patients often having a positive family history that is characterized by a similar phenotype. However, in atypical cases, particularly those in
Akinari Sekine +30 more
semanticscholar +1 more source
Advances in Kidney Disease and Health, 2023 Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. It has been associated with a significant physical and psychological burden, leading to a reduced quality of life. The purpose of this literature review is to summarize the patient perspective on ADPKD based on the current published literature.
Gittus, M., Harris, T., Ong, A.C.M.
openaire +3 more sources