Results 11 to 20 of about 8,048 (135)

Caring for Australians and New ZealandeRs with kidney Impairment guideline commentary on kidney disease: improving global outcomes 2025 guidelines for diagnosis and management of autosomal polycystic kidney disease. [PDF]

Intern Med J
Abstract Autosomal polycystic kidney disease (ADPKD) is the most common form of inherited kidney disease. The international guideline developer, Kidney Disease: Improving Global Outcomes (KDIGO), published a 2025 clinical practice guideline reflecting advances in genetic testing and the first disease‐modifying agent, tolvaptan.
Abdy ME, St Pierre K, Major E, Alexander SI, Cashmore B, Coolican H, Cullen V, Dawson J, Lambert K, Lee VW, Mallawaarachi A, Rangan G, Savige J, Varughese S, Tunnicliffe DJ, Mallett AJ, CARI Guidelines Steering Committee.   +16 more
europepmc   +2 more sources

HIF-Regulated Pannexin-1 Channel Drives Luminal ATP Accumulation in Kidney Cysts. [PDF]

FASEB J
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Skoczynski K, Scholz JK, Ursu R, Schödel J, Grampp S, Naas S, Lauer V, Schiffer M, Büttner-Herold M, Buchholz B, Kraus A.   +10 more
europepmc   +2 more sources

The BC ADPKD Network: A Comprehensive Provincial Approach to Support Specialized and Locally Delivered Multidisciplinary ADPKD Care

Canadian Journal of Kidney Health and Disease, 2021
Purpose: With evolving evidence around the progression, assessment, and management of autosomal dominant polycystic kidney disease (ADPKD), care of the disease has become increasingly complex.
M. Bevilacqua, S. Gradin, J. Williams, A. Romann, C. Lo, O. Djurdjev, A. Levin   +6 more
doaj   +1 more source

Cardiac structural and functional findings in Persian cats with autosomal dominant polycystic kidney disease [PDF]

Ciência Rural, 2020
: Autosomal dominant polycystic kidney disease (ADPKD) has been related to left ventricular structural and functional abnormalities in human patients. The present study aimed to evaluate the cardiac structural and functional findings in Persian cats with
Juliana Mariotti Guerra, Arine Pellegrino, Alexandre Gonçalves Teixeira Daniel, Mariana Ferreira de Freitas, Natália Cavalca Cardoso, Rebecca Bastos Pessoa, Gabriel Garone de Lucca, Maria Helena Matiko Akao Larsson, Luiz Fernando Onuchic, Felisbina Luisa Queiroga, Bruno Cogliati   +10 more
doaj   +1 more source

10-Year Evaluation of Adherence and Satisfaction with Information about Tolvaptan in ADPKD: A Single-Center Pilot Study

Patient Preference and Adherence, 2021
Holger Schirutschke, Peter Gross, Alexander Paliege, Christian Hugo University Hospital Carl Gustav Carus at the Technische, Universität Dresden, Department of Internal Medicine III, Division of Nephrology, Dresden, GermanyCorrespondence: Holger ...
Schirutschke H, Gross P, Paliege A, Hugo C   +3 more
doaj  

Exome sequencing of Saudi Arabian patients with ADPKD

Renal Failure, 2019
Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive development of kidney cysts and enlargement and dysfunction of the kidneys. The Consortium of Radiologic Imaging Studies of the Polycystic Kidney Disease (CRISP)
Fahad A. Al-Muhanna, Abdullah M. Al-Rubaish, Chittibabu Vatte, Shamim Shaikh Mohiuddin, Cyril Cyrus, Arafat Ahmad, Mohammed Shakil Akhtar, Mohammad Ahmad Albezra, Rudaynah A. Alali, Afnan F. Almuhanna, Kai Huang, Lusheng Wang, Feras Al-Kuwaiti, Tamer S. Ahmed Elsalamouni, Abdullah Al Hwiesh, Xiaoyan Huang, Brendan Keating, Jiankang Li, Matthew B. Lanktree, Amein K. Al-Ali   +19 more
doaj   +1 more source

PKD1 gene rs7185040 polymorphism and progression of chronic kidney disease in patients with ADPKD [PDF]

Journal of Nephropathology
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a commonly encountered genetic condition contributing to chronic renal failure in both pediatric and adult populations. Roughly 89% of individuals with ADPKD exhibit mutation in either
Aiswarya Kosaraju, Sandhya Suresh, Ramprasad Elumalai, Gnanasambandan Ramanathan   +3 more
doaj   +1 more source

A Comparison of Urine Dilution Ability between Adult Dominant Polycystic Kidney Disease, Other Chronic Kidney Diseases, and Healthy Control Subjects: A Case-Control Study

International Journal of Nephrology, 2020
The final dilution of urine is regulated via aquaporin-2 water channels in the distal part of the nephron. It is unclear whether urine dilution ability in autosomal dominant polycystic kidney disease patients (ADPKD patients) differs from other patients ...
M. H. Malmberg, F. H. Mose, E. B. Pedersen, J. N. Bech   +3 more
doaj   +1 more source

Clinical Utility and Tolerability of Tolvaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Drug, Healthcare and Patient Safety, 2022
Rupesh Raina,1– 3 Ahmad Houry,1,3 Pratik Rath,1 Guneive Mangat,1 Davinder Pandher,1,4 Muhammad Islam,3 Ala’a Grace Khattab,3 Joseph K Kalout,1 Sumedha Bagga5 1Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH, USA ...
Raina R, Houry A, Rath P, Mangat G, Pandher D, Islam M, Khattab AG, Kalout JK, Bagga S   +8 more
doaj  

Characterization of Primary Cilia in Osteoblasts Isolated From Patients With ADPKD and CKD

JBMR Plus, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of chronic kidney disease (CKD) and leads to a specific type of bone disease.
Renata C Pereira, Berenice Y Gitomer, Michel Chonchol, Peter C Harris, Kathleen J Noche, Isidro B Salusky, Lauren V Albrecht   +6 more
doaj   +1 more source