Results 21 to 30 of about 8,048 (135)

Executive Summary: Clinical Practice Guideline for Autosomal Dominant Polycystic Kidney Disease in China

Kidney Diseases, 2020
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, with a prevalence of 1/2,500–1/1,000, and it affects 1.25 million people in China.
Chang-Lin Mei, Cheng Xue, Sheng-Qiang Yu, Bing Dai, Jiang-Hua Chen, Ying Li, Li-Meng Chen, Zhang-Suo Liu, Yong-Gui Wu, Zhao Hu, Yan Zha, Hong Liu, Yong-Ze Zhuang, Chun Zhang, Xiang-Cheng Xiao, Yue Wang, Gui-Sen Li, Yi-Yi Ma, Lin Li   +18 more
doaj   +1 more source

Assessing Risk of Disease Progression and Pharmacological Management of Autosomal Dominant Polycystic Kidney Disease

Canadian Journal of Kidney Health and Disease, 2017
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disorder worldwide. The disease is characterized by renal cysts and progressive renal failure due to progressive enlargement of cysts and renal fibrosis. An estimated
Steven Soroka, Ahsan Alam, Micheli Bevilacqua, Louis-Philippe Girard, Paul Komenda, Rolf Loertscher, Philip McFarlane, Sanjaya Pandeya, Paul Tam, Daniel G. Bichet   +9 more
doaj   +1 more source

Acute Kidney Injury in ADPKD Patients with Pneumonia

International Journal of Nephrology, 2011
Background. In animal models, polycystic kidneys are susceptible to acute kidney injury (AKI). We examined the occurrence of AKI in a cohort of autosomal dominant polycystic kidney disease (ADPKD) and non-ADPKD patients with acute pneumonia. Design.
Carlos Franco Palacios, Mira T. Keddis, Dingxin Qin, Ladan Zand, Guangxi Li, Xiangling Wang, Rodrigo Cartin-Ceba, Robert P. Hartman, Qi Qian   +8 more
doaj   +1 more source

Unilateral autosomal dominant polycystic kidney disease with co-existent renal cell carcinoma: A rare entity

The Egyptian Journal of Radiology and Nuclear Medicine, 2018
Bilateral ADPKD is a well-known entity, but there are only a few reports on unilateral ADPKD in adults, most of which had associated contralateral agenesis. Further rare is the development of RCC in unilateral ADPKD.
Anupama Tandon, Mohd Shuaib Qureshi, Irfan Ahmad, Usha Rani Singh, Shuchi Bhatt   +4 more
doaj   +1 more source

Tolvaptan in Pediatric Autosomal Dominant Polycystic Kidney Disease: From Here to Where?

Kidney Diseases, 2021
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, accounting for approximately 5% of all ESRD cases worldwide.
Fei Liu, Chunyue Feng, Huijun Shen, Huaidong Fu, Jianhua Mao   +4 more
doaj   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Clinical Manifestation, Management and Prognosis of Acute Myocardial Infarction in Autosomal Dominant Polycystic Kidney Disease

Kidney & Blood Pressure Research, 2018
Background/Aims: Cardiovascular complications are the most common cause of death in individuals with autosomal dominant polycystic kidney disease (ADPKD), yet there is no substantial data concerning the clinical characteristics of acute myocardial ...
Bo Yang, Qi Wang, Rui Wang, Tao Xu
doaj   +1 more source

Rationale and study protocol of ACQUIRE, a prospective, observational study measuring quality of life, treatment preference and treatment satisfaction of autosomal dominant polycystic kidney disease (ADPKD) patients in Europe

BMC Nephrology, 2020
Background Autosomal dominant polycystic kidney disease (ADPKD) is considered the most common inherited renal disease. Patient-Reported Outcomes (PROs) and patient experience in ADPKD are difficult to quantify and have not been well studied, particularly
Dominique Joly, Jennifer Quinn, Stella Mokiou, Karl O’Reilly, Joaquín Sánchez-Covisa, Jing Wang-Silvanto, Helen Doll   +6 more
doaj   +1 more source

Epidemiology and Outcomes of Cryptococcal Infections in Liver Transplant Recipients: A Retrospective Cohort Study at a US Academic Center

Transplant Infectious Disease, EarlyView.
Among 346 liver transplant recipients, rural residence conferred a 3.3‐fold higher risk of cryptococcal infection — a novel finding suggesting environmental exposure or healthcare access barriers may drive susceptibility. Triple immunosuppression and longer waitlist duration were additional risk factors, with very early infection carrying the worst ...
Rachel Sigler, Chloe Hanigan, Atikur Rahman, Isuru Ratnayake, Phani Akella, Lauren Carlini, Chelsea Gorsline, Erica Mackenzie, Albert Eid, Dennis Shoemaker, Ryan Taylor, Stephen Waller   +11 more
wiley   +1 more source