Results 21 to 30 of about 12,370 (174)

Genetic and Pharmacological Investigations into a Zebrafish Model of ADPKD

, 2021
This research aimed to identify molecular mechanisms underlying autosomal dominant polycystic kidney disease (ADPKD) using genetic and pharmacological approaches in a zebrafish model of ADPKD.
Molind, Gregory John
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PKD1 gene rs7185040 polymorphism and progression of chronic kidney disease in patients with ADPKD [PDF]

Journal of Nephropathology
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a commonly encountered genetic condition contributing to chronic renal failure in both pediatric and adult populations. Roughly 89% of individuals with ADPKD exhibit mutation in either
Aiswarya Kosaraju, Sandhya Suresh, Ramprasad Elumalai, Gnanasambandan Ramanathan   +3 more
doaj   +1 more source

10-Year Evaluation of Adherence and Satisfaction with Information about Tolvaptan in ADPKD: A Single-Center Pilot Study

Patient Preference and Adherence, 2021
Holger Schirutschke, Peter Gross, Alexander Paliege, Christian Hugo University Hospital Carl Gustav Carus at the Technische, Universität Dresden, Department of Internal Medicine III, Division of Nephrology, Dresden, GermanyCorrespondence: Holger ...
Schirutschke H, Gross P, Paliege A, Hugo C   +3 more
doaj  

Measuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study. [PDF]

, 2012
Trials failed to demonstrate protective effects of investigational treatments on glomerular filtration rate (GFR) reduction in Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Buongiorno E, Flavio Gaspari, Pisani Antonio, Patrizia Ondei (180738), Stucchi Nadia, Piero Ruggenenti, Ruggenenti Piero, Giuseppe Remuzzi, Dugo Mauro, Prandini S, Perico N, PISANI, ANTONIO, Mauro Dugo (180745), Ruggenenti P, Messa P, Olimpia Diadei (180735), Piero Ruggenenti (180711), Ferrari S, Piergiorgio Messa, Piergiorgio Messa (180742), Olimpia Diadei, Patrizia Ondei, Cannata Antonio, Silvia Prandini (180731), Remuzzi Giuseppe, Ferrari Silvia, Carrara F, Fabiola Carrara (180719), Diadei O, Erasmo Buongiorno (180739), Buongiorno Erasmo, GFR-ADPKD Study Group, Mauro Dugo, Flavio Gaspari (180714), Cella C, Norberto Perico, Fabiola Carrara, GFR ADPKD Study Group, Antonio Cannata (180717), Diadei Olimpia, Nadia Stucchi (180729), Norberto Perico (180737), Perico Norberto, Silvia Prandini, Remuzzi G, Pisani A, Antonio Pisani (24903), Cella Claudia, Erasmo Buongiorno, Cannata A, Antonio Cannata, Silvia Ferrari (180726), Claudia Cella, Carrara Fabiola, Ene Iordache B, Ondei Patrizia, Prandini Silvia, Gaspari F, Nadia Stucchi, Messa Piergiorgio, Stucchi N, Antonio Pisani, Gaspari Flavio, Ondei P, Bogdan Ene-Iordache, Dugo M, Ene-Iordache Bogdan, Silvia Ferrari, Ene-Iordache B, Bogdan Ene-Iordache (180734), Claudia Cella (180722), Giuseppe Remuzzi (180748)   +71 more
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Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD [PDF]

, 2016
Background: Autosomal dominant polycystic kidney disease (ADPKD) causes progressive loss of renal function in adults as a consequence of the accumulation of cysts. ADPKD is the most common genetic cause of end-stage renal disease. Mutations in polycystin-
Boedigheimer, Michael, Harris, Peter C., de Almeida, Rita M. C., Richards, William G., Damore, Michael, Britney-Shea Herbert, Sandro Rossetti, Glazier, James Alexander, Herbert, Britney-Shea, Michael Boedigheimer, Almeida, Rita Maria Cunha de, Michael Damore, Damore, Michael A., Rita M. C. de Almeida, Peter C. Harris, Xu, Wei Min, Bacallao, Robert L., James A. Glazier, Richards, William Graham, Robert L. Bacallao, Wei Min Xu, Rossetti, Sandro, Herbert, Brittney Shea, Sherry G. Clendenon, Boedigheimer, Michael J., Angela Wandinger-Ness, William G. Richards, Wandinger-Ness, Angela, Clendenon, Sherry G., Glazier, James A., Heather H. Ward, Ward, Heather H.   +31 more
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A Comparison of Urine Dilution Ability between Adult Dominant Polycystic Kidney Disease, Other Chronic Kidney Diseases, and Healthy Control Subjects: A Case-Control Study

International Journal of Nephrology, 2020
The final dilution of urine is regulated via aquaporin-2 water channels in the distal part of the nephron. It is unclear whether urine dilution ability in autosomal dominant polycystic kidney disease patients (ADPKD patients) differs from other patients ...
M. H. Malmberg, F. H. Mose, E. B. Pedersen, J. N. Bech   +3 more
doaj   +1 more source

Is the light at the end of the tunnel nigh? A review of ADPKD focusing on the burden of disease and tolvaptan as a new treatment [PDF]

, 2018
Rashid A Barnawi,1 Rahaf Z Attar,1 Sultan S Alfaer,1 Osama Y Safdar2 1Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 2Pediatric Nephrology Center of Excellence, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia ...
Safdar OY, Barnawi RA, Rahaf Attar, Rashid Barnawi, Alfaer SS, Attar RZ, Osama Safdar, Sultan Alfaer   +7 more
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A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model [PDF]

, 2018
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients.
Gerd Walz, O'Reilly, K., Richard Sandford, Walz, Gerd, O'Reilly, Karl, Albert C. M. Ong, Cabrera, Maria-Cristina V, Hayley Bennett Wilton, Bennett Wilton H, McEwan P, Sandford, Richard, Sandford, R., Sandford R, McEwan, Phil, Scolari, Francesco, Bennett Wilton, Hayley, Scolari, F., Orskov, B., Walz G, Ong, A.C.M., Ørskov B, Bjarne Ørskov, Robinson, P., Phil McEwan, Cabrera, M.-C.V., Robinson, Paul, O’Reilly, Karl, Robinson P, McEwan, P., Walz, G., Maria-Cristina V. Cabrera, Wilton, H.B., Ong ACM, Cabrera MV, Ong, Albert C. M., O'Reilly K, Cabrera, Maria-Cristina V., Paul Robinson, Ong, Albert C M, Ørskov, Bjarne, Scolari F, Francesco Scolari, Karl O’Reilly   +42 more
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Clinical Utility and Tolerability of Tolvaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Drug, Healthcare and Patient Safety, 2022
Rupesh Raina,1– 3 Ahmad Houry,1,3 Pratik Rath,1 Guneive Mangat,1 Davinder Pandher,1,4 Muhammad Islam,3 Ala’a Grace Khattab,3 Joseph K Kalout,1 Sumedha Bagga5 1Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH, USA ...
Raina R, Houry A, Rath P, Mangat G, Pandher D, Islam M, Khattab AG, Kalout JK, Bagga S   +8 more
doaj  

LRP5 variants may contribute to ADPKD [PDF]

, 2016
Contains fulltext : 167912.pdf (Publisher’s version ) (Open Access)Mutations in Polycystic Kidney Disease proteins (PKD1 or PKD2) are causative for autosomal dominant polycystic kidney disease (ADPKD).
Hanka Venselaar, Carsten Bergmann, Losekoot, M., Drenth, J.P.H., Hoischen, Alexander, Cnossen, Wybrich R., Monique Losekoot, Wybrich R Cnossen, Breuning, M.H., Mehdi, S., Dorien JM Peters, Peters, D.J.M., Bergmann, C., Alexander Hoischen, Morsche, R.H. te, Gilissen, C.F., Breuning, Martijn H., Cnossen, W.R., Christian Gilissen, Joost PH Drenth, Soufi Mehdi, Venselaar, Hanka, Veltman, Joris A., Peters, D.J., Venselaar, H., Drenth, Joost P. H., Gilissen, C., Joris A Veltman, Morsche, Rene H. M. te, Veltman, J.A., Drenth, J.P., Hoischen, A., Peters, Dorien J. M., Gilissen, Christian, Losekoot, Monique, Mehdi, Soufi, Morsche, R.H.M.T., Bergmann, Carsten, René HM te Morsche, Martijn H Breuning   +39 more
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